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Author: PRAKASH KUMAR, B × End date: 2008 × Start date: 2000 ×
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    ThesisItemOpen Access
    HALOPERIDOL AS AN ADJUNCT TO BARBITURATE AND NON-BARBITURATE ANAESTHESIA IN DOGS
    (Sri Venkateswara Veterinary University, TIRUPATI – 517 502,A.P, 2003-09) PRAKASH KUMAR, B; R.V.SURESH KUMAR, R.V (Major); HARA GOPAL, V; SRILATHA, Ch
    ABSTRACT : Twelve healthy female dogs brought for animal birth control programme were divided into two groups of six animals each to study the effects of haloperidol as an adjunct to thiopentone sodium and ketamine hydrochloride. Haloperidol was given intravenously @ 0.87 mg/kg body weight in both the groups. All the dogs assumed sternal recumbency following haloperidol administration but were responding to painful stimuli. This was followed by administration of thiopentone sodium @ 20 mg/kg body weight and ketamine hydrochloride @ 10 mg/kg body weight in group I and group II respectively. The induction was smooth and rapid in group I but was delayed in group II. The mean duration of anaesthesia was 41.0 ± 0.94 minutes in group I where as it was 28.0 ± 4.09 minutes in group II which required incremental dose of ketamine approximately at 30 minutes of observation period. The recovery was smooth in group I, but associated with micturition, shivering and moderate vocalization in group II. Respiratory or heart rates showed significant decrease while temperature showed non-significant decrease in both the groups. PCV, Hb, ESR and TLC values decreased non-significantly in both the groups. BUN and creatinine levels showed transient non significant increase in group I and II. SpO2 values remained within the physiological limits in both the groups. ECG studies did not reveal any significant changes in PQ, PR, QRS complexes except primary T wave changes in two animals. The study suggests that the combination of haloperidol with thiopentone and ketamine were compatible and safe and are recommended for clinical use in dogs.