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Author: DHANA LAKSHMI, G × End date: 2010 × Start date: 2010 × Type: Thesis × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    STUDIES ON THE EVALUATION OF THE PROTECTIVE EFFCT OF TRIBULUS TERRESTRIS IN CADMIUM INTOXICATED RATS
    (SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI – 517 502. (A.P) INDIA, 2010-12) DHANA LAKSHMI, G; RAVI KUMAR, P; BHARAVI, K; ANNAPURNA, P
    ABSTRACT : Cadmium is one of the most toxic heavy metal naturally occurring in the environment. Cadmium has a tendency to accumulate in vital organs like liver and kidney for many years. Majority of the deleterious effects of cadmium are related to its potential to induce oxidative damage within the cells. Thus supplementation of antioxidants during cadmium intoxication would have beneficial effect. Tribulus terrestris (TT), a flowering plant belong to the family Zygophyllaceae, and widely prevalent locally is reported to have antioxidant properties. Hence, the protective effect of ethanolic extract of whole plant of TT was assessed in cadmium intoxicated rats. Forty Wistar strain male rats aged about 60 days were randomly assigned to 4 equal groups. Group I was maintained as control, while groups II, III and IV rats received cadmium @3mg/kg body weight s/c once a week for 4 weeks. In addition, group III rats were administered with TT extract @ 5mg/kg body weight per os daily for 6 weeks while group IV rats received vitamin E @ 75mg/kg body weight per os daily for 6 weeks. All the rats were sacrificed at the end of 6th week. Cadmium toxicity in group II rats was manifested as a decrease in body weight gain, decrease in antioxidant markers viz., SOD, GSH and CAT, increase in peroxidation markers viz., TBARS and protein carbonyls, in liver and kidney, decrease in total proteins, albumin and globulin in serum and increase in ALT, BUN and creatinine in serum. Alterations in histological architecture and increased cadmium concentration were also observed in livers and kidneys following cadmium intoxication. In groups III and IV that received TT and vitamin E supplementation along with cadmium, a reversal in the biochemical alterations induced by cadmium was observed. This trend was in agreement with improved body weight gain and less severe histological changes and reduced cadmium load in liver and kidneys. It was apparent from the study that ethanolic extract of TT has protective effect in cadmium induced oxidative damage in liver and kidney tissues.