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20172
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Subject: Veterinary Surgery and Radiology × Author: VAMSY KRISHNA YADAV, D × Start date: 2000 ×
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    ThesisItemOpen Access
    STUDIES ON SPARING EFFECT OF BUTORPHANOL AND KETAMINE FOR XYLAZINE / DEXMEDETOMIDINE INDUCTION ON ISOFLURANE ANAESTHESIA FOR ELECTIVE OVARIOHYSTERECTOMY IN DOGS
    (SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2017-01) VAMSY KRISHNA YADAV, D; BHARATHI, S(MAJOR); DEVI PRASAD, V; VENKATA NAIDU, G
    ABSTRACT: The present study was conducted to compare the sparing effect of Dexmedetomidine, Butorphanol, Ketamine combination (group I) and Xylazine, Butorphanol, Ketamine combination (group II) induction on isoflurane for elective ovario hysterectomy in twelve bitches which were divided into two groups of six animals each. Both groups received Atropine sulphate @ 0.02 mg/kg b.wt. sc. 20 minutes prior to induction of anaesthesia. In group I all bitches were given same dose rates of induction combination of drugs i.e., Dexmedetomidine @ 5 μgm/kg b.wt, Butorphanol @ 0.1 mg/kg b.wt and Ketamine @ 1mg/kg b.wt. and in group II all animals received Xylazine @ 0.2 mg/kg b.wt, Butorphanol @ 0.1 mg/kg b.wt and Ketamine @ 1mg/kg b.wt mixed in a single syringe and administered intravenously followed by maintenance with Isoflurane in oxygen. The dose rates of drugs required for quick induction of general anaesthesia in group I were found to be Dexmedetomidine @ of 6 μgm/kg b.wt, Butorphanol @ 0.1 mg/kg b.wt and Ketamine @ 4mg/kg b.wt. and in group II, it was Xylazine @ 0.6 mg/kg b.wt, Butorphanol @ 0.1 mg/kg b.wt and Ketamine @ 4mg/kg b.wt. Good quality of induction was seen in group II compared to group I. The changes in body temperature, cardiovascular, pulmonary, haemato-biochemical parameters were studied. Hb, PCV, TEC and TLC decreased from pre-medication to recovery in both the groups. The cardiovascular parameters increased up to maintenance and respiratory parameters showed reduction during induction and increased during maintenance and decreased during recovery. Serum biochemical parameters showed non-significant changes in both groups. The time for extubation and time for total recovery from anaesthesia was lower in group II. The mean vaporizer setting for maintenance and total quantity of isoflurane consumed was lower in group II compared to group I. It is concluded that Butorphanol and Ketamine combination with Xylazine had more sparing effect on Isoflurane when compared to Butorphanol and Ketamine with Dexmedetomidine on isoflurane in dogs that underwent elective ovariohysterectomy
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    ThesisItemOpen Access
    STUDIES ON SPARING EFFECT OF BUTORPHANOL AND KETAMINE FOR XYLAZINE / DEXMEDETOMIDINE INDUCTION ON ISOFLURANE ANAESTHESIA FOR ELECTIVE OVARIOHYSTERECTOMY IN DOGS
    (SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI – 517 502. (A.P) INDIA, 2017-01) VAMSY KRISHNA YADAV, D; BHARATHI, S(Major); DEVI PRASAD, V; VENKATA NAIDU, G
    ABSTRACT: The present study was conducted to compare the sparing effect of Dexmedetomidine, Butorphanol, Ketamine combination (group I) and Xylazine, Butorphanol, Ketamine combination (group II) induction on isoflurane for elective ovario hysterectomy in twelve bitches which were divided into two groups of six animals each. Both groups received Atropine sulphate @ 0.02 mg/kg b.wt. sc. 20 minutes prior to induction of anaesthesia. In group I all bitches were given same dose rates of induction combination of drugs i.e., Dexmedetomidine @ 5 μgm/kg b.wt, Butorphanol @ 0.1 mg/kg b.wt and Ketamine @ 1mg/kg b.wt. and in group II all animals received Xylazine @ 0.2 mg/kg b.wt, Butorphanol @ 0.1 mg/kg b.wt and Ketamine @ 1mg/kg b.wt mixed in a single syringe and administered intravenously followed by maintenance with Isoflurane in oxygen. The dose rates of drugs required for quick induction of general anaesthesia in group I were found to be Dexmedetomidine @ of 6 μgm/kg b.wt, Butorphanol @ 0.1 mg/kg b.wt and Ketamine @ 4mg/kg b.wt. and in group II, it was Xylazine @ 0.6 mg/kg b.wt, Butorphanol @ 0.1 mg/kg b.wt and Ketamine @ 4mg/kg b.wt. Good quality of induction was seen in group II compared to group I. The changes in body temperature, cardiovascular, pulmonary, haemato-biochemical parameters were studied. Hb, PCV, TEC and TLC decreased from pre-medication to recovery in both the groups. The cardiovascular parameters increased up to maintenance and respiratory parameters showed reduction during induction and increased during maintenance and decreased during recovery. Serum biochemical parameters showed non-significant changes in both groups. The time for extubation and time for total recovery from anaesthesia was lower in group II. The mean vaporizer setting for maintenance and total quantity of isoflurane consumed was lower in group II compared to group I. It is concluded that Butorphanol and Ketamine combination with Xylazine had more sparing effect on Isoflurane when compared to Butorphanol and Ketamine with Dexmedetomidine on isoflurane in dogs that underwent elective ovariohysterectomy.