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20031
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Subject: Veterinary Surgery × Author: MALLIKARJUNA RAO, Ch × End date: 2009 × Start date: 2000 ×
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    ThesisItemOpen Access
    STUDIES ON INFLUENCE OF PHENOTHIAZINE AND BENZODIAZEPINE TRANQUILIZERS ON PROPOFOL ANAESTHESIA IN DOGS
    (Sri Venkateswara Veterinary University, TIRUPATI – 517 502,A.P, 2003-09) MALLIKARJUNA RAO, Ch; HARA GOPAL, V (Major); SURESH KUMAR, R.V; SRILATHA, Ch
    ABSTRACT : Twelve dogs were utilized to study the effects of propofol on induction and maintenance after premedication with triflupromazine hydrochloride and diazepam. The animals were divided into two groups of six animals in each group. Triflupromazine hydrochloride@ 1 mg/ kg body weight and diazepam @ 0.5 mg/kg body weight were given intravenously in group I and group II respectively. Propofol was given intravenously @ 5mg/kg body weight after premedication and maintained by continuous infusion of propofol @ 0.4 mg/kg/minute in 5 per cent dextrose normal saline in both the groups. Induction was smooth and excellent in both the groups. Diazepam premedicated animals showed good muscle relaxation and abolition of all reflexes were noticed early than group I. The recovery from anaesthesia was smooth without any postanaesthetic complications in both the groups. Rectal temperature and respiratory rate did not show any significant changes between two groups. Heart rate did not show any significant fall in group I and significant fall up to 15 minutes in group II followed by gradual increase to near normally in remaining period. Sp02 values were within normal range during the entire period of observation. Electrocardiographic findings revealed no arrhythmias and conduction abnormalities in both the groups. The various haematological parameters like packed cell volume (PCV), haemoglobin(Hb) values did not show any significant decrease. Significant difference between two groups in packed cell volume (PCV) and haemoglobin(Hb) were noticed. Erythrocyte sedimentation rate (ESR) did not show any significant changes in both the groups. Changes in the Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) values were not significant and within normal range in both the groups.