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Subject: Veterinary Pharmacology and Toxicology × Author: ANURADHA, K × End date: 2005 × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    EVALUATICN OF HYPOLIPIDEMIC ACTIVITY OF ZINGZIBER OFFICINALE ROSCOE AND BACOPA MONNIERI LINN. IN HYPERLIPIDEMIC BATS
    (SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2005-12) ANURADHA, K; VENKATESWARLU, U(MAJOR); ADILAXMAMMA, K; SURESH KUMAR, R.V
    ABSTRACT: The present study was conducted to find out the hypolipidemic activity of Zingiber oflcinale Roscoe containing 5% gingerois i& 4480 mglkg b.wt and 20% gingerols @ 120 mgkg b.wt and Bacopa monnieri Linn. @ 20 and 40 mgkg b.wt and compared the same with that of atorvastatin, a standard hypolipidemic drug (ii? 8 rnglkg b.wt in triton and diet-induced modcls of h! perlipidemia. In triton-induced model the serum total cholesterol and triglycerides were monitored at intervals of 0,18, 24 and 40 hours. There was a significant (Pi0.05) elevation in total cholesterol and triglycerides at 18. 24 and 40 hours post administration of triton, which was significantly (P4.05) decreased by Z, oflic.irrtrlc~. 8. monnieri @j 40 mgikg and atorvastatin. In diet-induced model the serum lipid profile was monitored on Days 0,15 and 30. At the end of the Day 30, animals were sacrificed and liver was collected for estimation of liver lipid profile and lipid peroxidation. Liver and aorta samples were collected for histopathological examination. There was a significant (P<0.05) increase in the serum total cholesterol, triglycerides, VLDL, LDL and phospholipid concentrations of hyperlipidemic group, which was significantly (Pc0.05) reduced by Z. oflcinale and atorvastatin on both Day 15 and Day 30 whereas, B. monnieri significantly (Pc0.05) reduced the concentrations on Day 30 but the reduction of LDL concentrations was not significant (Pc0.05). There was a significant (P