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Subject: Veterinary Pathology × Author: POOVIZHI, K × End date: 2006 × Start date: 2000 × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    STUDIES ON INCIDENCE OF NEOPLASMS IN CANINES
    (SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2005-09) POOVIZHI, K; SRILATHA, Ch(MAJOR); SUJATHA, K; SURESH KUMAR, R.V
    ABSTRACT : Cancer is one of the major causes of morbidity and mortality in pet dogs and humans. Approximately 25% of humans and approximately 30% of older dogs will develop cancer during their lifetime. There is a tremendous increase in the interest of canine malignancies. So it is very much important to know about features of cancers and their incidence for diagnosis, prognosis and as well as for the proper treatment. A total of 53 canine tumour cases were collected during present study with the relevant clinical data. Histologically they were classified into discrete round cell tumours, mesenchymal tumours, epithelial cell tumours and mixed tumours Out of 53 cases the incidence was 18.86, 13.21, 62.23 and 5.66 percent in round cell tumours, mesnchymal tumours, epithelial tumours and mixed tumours respectively. The benign tumours were 47.2 percent whereas malignant tumours were 52.8 percent. The highest incidence was recorded in 6 to 8 years age group (43.4 percent), followed by more than 10-year age group (24.53 percent). The highest incidence was noticed in female dogs (69.8 percent), whereas 30.19 percent was observed in males. Among the breeds affected, Non-descriptive breeds were the most common (41.51 percent) followed by Spitz (30.19 percent), German shepherd (18.87 percent), Doberman (3.78 percent) and Labrador, Boxer and Terrier each one case (1.89 percent). Mammary gland tumours were observed in 6 to 16 years age group. Breeds affected were Spitz (7), German shepherd (4), Doberman (2), Non-descriptive (2) and Labrador (1). Growths were located in abdominal pair (4), inguinal (7), thoracic and abdominal (1), abdominal and inguinal (3) and thoracic, abdominal and inguinal (1). Out of 53 cases the highest incidence was recorded in mammary glands (30.19 per cent), followed by transmissible venereal tumour (15.09 per cent), basal cell tumour and papilloma (5.66 per cent). Mast cell tumour, fibroma, lipoma, pancreatic exocrine adenocarcinoma, amyloblastoma and setolicell tumours were seen in each two cases (3.78 per cent). Myxoma, osteosarcoma, melanoma, squmaous cell carcinoma, apocrine adenocarcinoma, sebaceous gland adenoma, prostatic adenocarcinoma and tricoepithelioma were seen in each one case (1.89 per cent). Mammary gland tumours were further classified into Simple adenoma (1), Adenocarcinoma (7), Solid adenocarcinoma (1), Anaplastic carcinoma (2), Papillary adenocarcinoma (1), Papillary cystic adenocarcinoma (2), Tubular adenocarcinoma (1), Benign mixed mammary gland tumour (6), and Malignant mixed mammary gland tumour (2). Cytopathology of transmissible venereal tumour, mast cell tumour, fibroma, myxoma, osteosarcoma, lipoma, melanoma, basal cell carcinoma and pancreatic exocrine adenocarcinoma revealed characteristic cellular features. The mean AgNOR count for all of the individual tumours varied from 2.4 to 8.83. The mean number of AgNOR in benign tumours and in malignant tumours was 3.59 and 5.74 respectively. Anaplastic carcinomas have the highest AgNOR value (8.83). There was a difference between the CRP values of benign and malignant tumours and no difference was observed between control and benign group. In the present study 33.33 percent of tissues shown positivity to p53 and 25 percentages to p120. C-erb B2 immunoreactivity was observed in only one benign mixed tumour (8.33 percent). Positive reactivity to p120 and p53 was observed in anaplastic, tubular adenocarcinoma and solid carcinoma.