Thumbnail Image

Thesis

Browse

20051
Reset filters
Subject: Veterinary Medicine × Author: VIVEK RAMRAO, KASARALIKAR × End date: 2009 × Start date: 2000 × Type: Thesis × Thesis Type: Ph.D ×
Reset filters

Search Results

Now showing 1 - 1 of 1
  • Thumbnail Image
    ThesisItemOpen Access
    PRIMARY RUMINAL DYSFUNCTION IN GOATS WITH PARTICULAR REFERENCE TO LACTIC ACIDOSIS
    (SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2005-03) VIVEK RAMRAO, KASARALIKAR; ALAHA SINGARI, N(MAJOR); PRASANNA KUMAR, S; HAFEEZ, Md.; NALINIKUMARI; ESHWAR PRASAD, P
    ABSTRACT: The study was undertaken to find out the incidence of ruminal acidosis in goats in and around Bidar (Karnataka) during the period from January 2000 to December 2003 and to evolve an effective therapeutic regimen for the condition. The overall incidence of ruminal acidosis in goats was 9.67 per cent. It was more in the goats of 2-3 years of age (48.77%) with a higher frequency in females (90.70%) and maximum occurrence in the month of October. In the experimental study, acidosis was induced by administration of crushed rice @ 40 g/kg body weight. These goats were randomly divided into three groups. Group I was kept as untreated control and conventional and improved therapy was given at 24 hours post induction (PI) to Group II and III respectively. Clinical signs suggestive of acute ruminal acidosis like distended abdomen, profound dullness, grinding of teeth, regurgitation through nostrils and recumbency were observed with death of two in untreated control group. Gradual disappearance of clinical signs was noticed in treated groups and normalcy was resumed in 4 to 6 days after treatment (AT). Significant (P < 0.01) increase in heart rate was observed persisting up to 192 hours PI in untreated control group and normalcy was restored 48 hours earlier with improved therapy. Elevated haemogram and leucogram in untreated control group was suggestive of significant haemoconcentration whereas, in treated groups normal levels were noted at 36 hours AT. There was complete ruminal atony consequent to the induction of acidosis with reappearance of normal contractions at 84 and 120 hours AT with improved (G-III) and conventional therapy (G-II) respectively. Milky green, sour and watery rumen fluid at 12 hours PI with absence of protozoal concentration, iodophilic activity, total protozoal count and signi-ficant increase (P < 0.01) in methylene blue reduction time, sedimentation activity time, decrease in pH and reduced glucose fermentation activity was observed at 24 hours PI. These changes persisted in untreated control group up to 168 to 192 hours whereas; normalcy was restored in treated groups between 60 to 168 hours AT, which was 24 to 72 hours earlier with improved therapeutic regimen. Investigation on blood biochemical parameters revealed significant (P < 0.01) increase in glucose, lactic acid, lactate dehydrogenase, aspartate amino-transferase and sodium and decrease in potassium. Goats treated with improved therapy showed early return (24 to 48 hours) of normal values in all biochemical parameters compared to conventional therapy. Higher efficacy of the improved therapeutic regimen established in experimental study was re-evaluated in the clinical cases of acidosis brought to the hospitals. The observations in the clinical cases showed similar trends of change in clinico-haematological, rumen fluid characters and biochemical parameters as that of experimental study. All these parameters showed early return to normalcy in the group receiving improved therapy (Group V) compared to conventional therapy (Group IV). As improved therapy was found to be more effective in experimental (83.33%) and clinical study (94.12%) over conventional therapy, the improved therapeutic regimen consisting of isotonic sodium bicarbonate and thiamine by parenteral route and chloramphenicol, magnesium hydroxide and cud transplant PO used in present study is proposed as the preferred treatment protocol for the treatment of ruminal acidosis in goats.