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20201
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Subject: Veterinary Medicine × Author: CHAITANYA, YALAVARTHI × Start date: 2010 ×
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    ThesisItemOpen Access
    CLINICO-DIAGNOSTIC AND THERAPEUTIC STUDIES ON RENAL DISEASE IN DOGS
    (SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2020-12) CHAITANYA, YALAVARTHI; LAKSHMI RANI, N (MAJOR); VAIKUNTA RAO, V; RAVI KUMAR, P; SREENU, MAKKENA
    During the study period of two years, the occurrence of renal diseases in dogs accounted up to 3.40 per cent in. Among the affected dogs, 18.24 per cent suffered with acute kidney injury, whereas 81.76 per cent were of chronic kidney disease. Kidney diseases were more prevalent in male dogs, aged above 8 years and the occurrence was more in Pomeranian (30.82%). In the affected dogs, the clinical presentation varied from asymptomatic to typical clinical signs. Detailed haemato- biochemical examination and imaging studies performed in 128 dogs revealed that, 25 dogs were affected with AKI and 103 dogs had CKD. The dogs with CKD were further categorized into four stages based on SDMA values as stage I, II, III and IV. The SDMA values in the affected dogs ranged from 14 to 152 μg/dL. Sub staging of CKD dogs was done based on UPC and Blood pressure. Significant difference (P0.05) was noticed in mean values of PI and RI in acute kidney injury and chronic kidney disease stage I and II with the healthy control while the same in chronic kidney disease stage III and IV varied significantly (P0.05) was noticed in mean values of LA/Ao and M mode echocardiographic findings in dogs with acute kidney injury which varied significantly (P<0.05) in chronic kidney disease. Therapy was initiated in dogs with kidney diseases by using herbal antioxidant, diuretic, phosphate binders, antibiotics, diuretic, ACE inhibitors, nutritional therapy, haematinics, fluid therapy along with specific treatment and were monitored for a period of 3 months. The survival percentage of dogs with acute kidney injury (Group I) was 84.00% per cent (21/25). The survival percentage was 100.00 per cent in Group IIa (17/17) and IIb (15/15) i.e., chronic kidney disease stage I and stage II, where as it was 80.00 per cent (20/25) in CKD stage III (Group IIc) and 56.00 per cent (26/46) in chronic kidney disease stage IV (Group IId). Significant difference (p<0.05) was recorded in the SDMA/creatinine ratio(9.20±0.18 in survivors vs 12.07 ± 0.42 in non survivors, BUN ( 82.53±1.84 mg/dL vs 148.62±12.82mg/dL), product of calcium and phosphorus(58.22±2.02 vs 89.32±1.92), sodium to potassium ratio (39.42±1.02 vs 48.93±1.32) , UPC (1.92±0.22 vs 3.86±0.52 ) and resistive index (0.62±0.56 vs 0.74±0.24) between survivors and non survivors