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Subject: Veterinary Medicine × Author: CHAITANYA, YALAVARTHI × End date: 2009 × Start date: 2005 × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    CLINICO-THERAPEUTIC STUDIES ON DYSPEPSIA WITH PARTICULAR REFERENCE TO HEPATIC INVOLVEMENT IN CANINE
    (SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2008-12) CHAITANYA, YALAVARTHI; TIRUMALA RAO, D.S(MAJOR); HAMZA, P.A; GIREESH KUMAR, V
    ABSTRACT: The Present investigation was conducted to study clinical, haemato-biochemical, ultrasonographic findings, and therapeutic efficacy of certain drugs in dogs with dyspepsia with particular reference to hepatic involvement in canine. During the period of 8 months of present study, 30 dogs with hepatic involvement were selected basing on serum biochemical findings. Dyspepsia (100%) was the most common complaint followed by vomiting (80%), lethargy (57%), ascites (53%), diarrhea (33%), anemia (23%), melena (20%), jaundice (13%), fever(13%) and neurological signs(7%) . Elevated levels of serum ALT,serum ALP, serum GGT, total bilirubin and hypoproteinemia, hypoalbuminaemia and hypoglycemia were most important biochemical alterations in dogs with dyspepsia and hepatic involvement. After therapy a significant (p< 0.05) improvement was noticed in Hb, serum ALP, serum GGT, total protein and glucose levels in group-I. Similarly in group II, a significant (p< 0.05) improvement was seen in TEC, TLC, Hb, ALT, ALP, GGT, total protein, albumin, glucose levels. In group III, a significant (p< 0.05) improvement was seen in TEC, TLC, Hb, DLC, ALT, ALP, GGT, total protein, albumin, glucose levels, total bilirubin levels were significant in group III(p< 0.05). In the present study 10 cases were randomly selected for ultrasonography on the basis of available clinical, laboratory and morphological records. The relative efficacy of certain drugs was evaluated. The group I dogs received a combination of orally administered silymarin and iron supplement along with fluids (DNS) parenterally. The group II dogs received a combination of liver extract and B-complex vitamins and iron supplement along with fluids (DNS) parenterally. The therapeutic efficacy of this group was significant (p < 0.05) on day 7. This therapeutic regimen was useful in treating mild cases where infectious agent was not involved. The group III dogs received a combination of liver extract and B-complex vitamins, prednisolone and antibiotics along with fluids (DNS) parenterally. The therapeutic efficacy of this group was significant (p < 0.05) on day 7. This therapeutic regimen was useful in treating severe cases where infectious agent was involved and also in cirrhotic cases. Based on the findings of the present investigation it could be concluded that dyspepsia has involvement with sub optimal functional status of liver. It was concluded from this study that hepatic involvement and its complications can be cured successfully in dogs by conservative therapy if diagnosed at an early stage of the ailment.