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Subject: Veterinary Gynaecology and Obstetrics × Author: HARI PRIYA, P × Start date: 2020 × Type: Thesis × Thesis Type: M.V.Sc. ×
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    ThesisItemOpen Access
    EVALUATION OF THERAPEUTIC EFFICACY OF DIFFERENT PROTOCOLS IN THE TREATMENT OF TRANSMISSIBLE VENEREAL TUMOUR IN BITCHES
    (SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2021-04) HARI PRIYA, P; SRINIVAS, M (MAJOR); SADASIVA RAO, K; LAKSHMI RANI, N
    The present investigation was conducted to study the efficacy of Vincristine (Group 1, n=8) and Vincristine plus L-Asparaginase (Group 2, n=8) in the treatment of TVT in bitches. Detailed clinical, vaginal cytological and ultrasonographic examination was undertaken in bitches (n=277) with abnormal vaginal discharge and perineal deformity. The diagnostic evaluation revealed that open pyometra/CEH (47.29%) and TVT (18.77%) were the most predominant gynaecological conditions. Risk factors associated with development of the TVT revealed that 2-4 year old bitches (53.84%) of non-descript & cross breed (46.15%) were more commonly affected. Further, higher number of bitches after two to three months after last estrous cycle (69.23%), which whelped for one or two times (78.85%) due accidental mating (75.0%) had greater occurrence of TVT. Clinical signs exhibited by the affected bitches includes, visibility of tumour (78.84%), vaginal bleeding (100.0%), perineal deformation (50.00%), licking of genitals (82.70%), abnormal odour (90.38%) and dysuria (1.92%). Higher percentage of bitches had tumour located at the vestibulo-vulvar junction (44.23%) which were medium sized (50.85%) friable, diffuse, multiple and lobulated (55.76%) that frequently oozed frank blood (44.23%). The cellular characterization of the TVT cells revealed a higher percentage of lymphocytic type (73.08%), lower percentage of mixed variants (17.31%) and plasmacytic type (9.61%). The alterations in the haemogram suggested that Group 1 bitches exhibited decreased haemoglobin, PCV and total erythrocyte concentration, while Group 2 bitches had decreased haemoglobin and PCV concentrations. Bitches of both the groups exhibited anaemia and lymphocytosis during the course of chemotherapy. Increase in serum metabolites (BUN, Creatinine) and serum enzymes (AST, ALT) occurred on days 14 and 21 of treatment, but were within the normal reference range. Therapeutic efficacy or cure rate based on gross remission, cytological cure and side effects revealed that the mean cytological recovery time for vincristine plus L-Asparaginase combination protocol was lesser (3.0 weeks) as compared to treatment with Vincristine alone (4.13 weeks). The side effects recorded in Group 2 revealed that lesser number of bitches experienced side effects with lowered intensity as compared to Group 1 bitches. Thus, it was concluded that combination protocol of Vincristine and L-Asparaginase was effective and safe, which could be considered as suitable alternative in the treatment of CTVT.