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ThesisItem Open Access EFFECT OF ALPHA-LIPOIC ACID AND VITAMIN E ON THE PERFORMANCE, ANTIOXIDATION AND IMMUNE RESPONSE IN BROILER CHICKEN(SRI VENKATESWARA VETERINARY UNIVERSITY TIRUPATI - 517 502. (A.P.) INDIA, 2008-11) SRILATHA, T; RAVINDER REDDY, V(MAJOR); Qudratullah, S; Raju, M.V.L.NABSTRACT : The present experiment was conducted to study the effects of graded levels of alpha-lipoic acid (0, 20, 40, 60, 80 mg/kg), vitamin E (10, 50 mg/kg) and their combination in a 5 x 2 factorial manner on the performance, antioxidation and immune response of broiler chicken. A total of 400 day-old male commercial broilers were divided into 10 treatment groups with 8 replications (5 broilers in each) and fed one of the test diets till 6 weeks of age (starter 0-4 weeks and finisher 5–6 weeks). Body weight gain of broilers was not influenced by inclusion of Lipoic acid during starter phase. However, lipoic acid at 80 mg/kg had significantly (P< 0.05) higher body weight gain during finisher phase and also in over all period. Supplementation of various levels of lipoic acid, vitamin E and their combination did not influence feed intake of broilers. The inclusion of lipoic acid did not affect the FCR of broilers in over all period. Vitamin E did not influence FCR in starter and finisher periods. However, vitamin E at 50 mg/kg improved FCR in the over all period. Combination of lipoic acid and vitamin E also did not affect the FCR in the over all period. Livability was not influenced. The dressing yields and weights of liver, heart and gizzard were not influenced by various dietary treatments, but vitamin E at 50 mg/kg significantly (P<0.05) increased gizzard weights compared to control. Supplementation of lipoic acid at various levels did not affect the abdominal fat deposits, except at 20 mg/kg where the abdominal fat content was significantly (P<0.05) lowered. Lipoic acid at 20 and 80 mg/kg had significantly (P<0.05) higher breast yield percent than control. Lipoic acid at 60 mg/kg had significantly (P<0.05) higher spleen weight than control. Weight of bursa was not influenced by the inclusion of lipoic acid. The level of Vitamin E did not influence the weight of spleen and bursa. The combination of lipoic acid and vitamin E level influenced the weight of spleen but not bursa. The humoral immune response to NDV at 28 days of age significantly (P<0.05) increased with the inclusion of lipoic acid at 20 and 80 mg/kg plus vitamin E 50 mg/kg than control. Similarly, vitamin E at 50 mg/kg significantly (P<0.05) increased HI titres compared to its lower level of 10 mg/kg. At the age of 42 days, HI titers were significantly (P<0.05) higher in all diets supplemented with lipoic acid than control. Cell mediated immunity in terms of CBH response was significantly (P<0.05) higher on diets that contained lipoic acid at 60 and 80 mg/kg than control. Similarly, vitamin E at 50 mg/kg also had significantly (P<0.05) higher CBH than vitamin E at 10 mg/kg. Combination of lipoic acid and vitamin E did not influence CBH. Supplementation of lipoic acid and vitamin E influenced the activities of lipid peroxidase. MDA levels were significantly (P<0.05) reduced on all dietary treatment groups compared to the control diet. Supplementation of lipoic acid in all dietary treatment groups increased glutathione peroxidase levels. RBC catalase levels significantly (P<0.05) increased on diets contained lipoic acid at 60 mg/kg. It is concluded that Lipoic acid at 80 mg/kg and Vitamin E at 50 mg/kg may be supplemented to the broiler diet for improved growth, antioxidant status and better immune responses.