Browsing by Author "Thangapandiyan, M, et al.,"
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ArticleItem Open Access Calcinosis Cutis in a Pug Dog – A Case Report(2020-09) Pazhanivel, N; Saahithya, R; Thangapandiyan, M, et al.,; TANUVASA three-year-old male Pug dog was brought to the veterinary clinic with the history of skin lesions. Gross examination revealed bilateral symmetrical ulcerated plaques with erythematous papules in the axillary region and multifocal well demarcated plaques with erythematous papules on the ventral part of the abdomen. Microscopic examination revealed mild hyperkeratosis, parakeratosis and acanthosis. Multifocal mineralization with complete replacement of the collagenous connective tissue fibers and hair follicles in the dermis was seen. The case was confirmed as calcinosis cutis and this was further confirmed by von Kossa stain.ArticleItem Open Access Pathomorphology of malignant melanoma in a canine spleen(2019) Mohanpriya, T; Sridhar, R; Thangapandiyan, M, et al.,; TANUVASA case of malignant melanoma was recorded in a four year old female Ro weiler. Grossly, four subcapsular smooth nodules of varying sizes were observed on the parietal surface and one smooth nodule on the visceral surface. On section, the nodule was soft, dirty grey-black, circumscribed and appeared as two distinct areas separated by parenchyma. Cytology revealed oval to polygonal cells containing black granular cytoplasmic pigments, obscuring the nuclear details. Anisocytosis, anisokaryosis, variable nuclear:cytoplasmic ratio, prominent nuclei were seen. Histopathologically, the neoplastic cells were round to spindle to polyhedral in shape with severe/deep and brown black pigmented cytoplasm. On special staining with Fontana, the granules of neoplastic cells stained black and nuclei stained pink. The tissue was then subjected to proliferation marker Ki-67 immunohistochemistry, where more than 75% of neoplastic cells showed strongly positive immunolabelling.