Browsing by Author "Shahana, S"
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ArticleItem Open Access Antigenotoxic Effect of Nano-quercetin on 7,12-dimethylbenz[a]anthracene Induced Genotoxocity in Sprague Dawley Rats(2019) Shahana, S; Madheswaran, R; Balachandran, P; Arivuchelvan, A; Balasubramaniam, GA; TANUVASAgents that inhibit DNA adduct formation, stimulate DNA repair mechanisms and possess antioxidant functions are considered antigenotoxic agents. An investigation was undertaken as the antigenotoxic effect of quercetin and nanoquercetin against 7,12 dimethylbenz[a]anthracene (DMBA) induced genotoxicity by analysing the frequency of micronucleated polychromatic erythrocytes (MnPCEs). Elevated MnPCEs frequency was observed in DMBA group. Treatment with quercetin and nano-quercetin reduced the frequency of micronucleus formation. It was *Part of the M.V.Sc., thesis of the rst author submitted to the TANUVAS, Chennai-51. 1Corresponding author: Email : shahanaabi148@gmail.com R.Thangadurai and P.S.Shanmugam The Indian Veterinary Journal 36 (December, 2019) demonstrated that nano-quercetin reduced the micronucelus frequency against DMBA induced genotoxicity in the female Sprague Dawley rats.ArticleItem Open Access A case report of non-systemic highly aggressive melanoma in a cow(Indian Association of Veterinary Pathologists, 2019-04) Madheswaran, R; Shahana, S; Gopal, K; Sankar, P; TANUVASA five-year-old Jersey cow with a history of growing mass in the brisket region since 5 months was brought for the treatment at Veterinary Hospital. The radiographic details of the animal revealed no metastasized masses in the distant organs like heart and lungs. Grossly, the cut surfaces of growing mass was dark blackish with shades of brown colour. Microscopically, the growth revealed proliferating neoplastic melanocytes differentiated to form solid sheets, cellular clusters and parallel cords. The neoplastic cells were invaded into nearby blood vessels indicative of micrometastasis. The cells were pleomorphic in nature laden with dark brown to black coloured melanin pigment. The nuclei were hyperchromatic contained 2-3 prominent nucleoli. Few multinucleated giant cells and high mitotic figures were also seen. The melanin pigment was confirmed by Masson-Fontana-Silver staining technique. The histopathological characteristics with micrometastasis and radiography were indicative of non-systemic melanoma.