Browsing by Author "Seerangan, Rangasamy"
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ArticleItem Open Access Fabrication of Progesterone-Loaded Nanofibers for the Drug Delivery Applications in Bovine(2017) Karuppannan, Chitra; Sivaraj, Mehnath; Ganesh Kumar, J; Seerangan, Rangasamy; Balasubramanian, S; Gopal, Dhinakar Raj; TANUVASProgesterone is a potent drug for synchronization of the estrus and ovulation cycles in bovine. At present, the estrus cycle of bovine is controlled by the insertion of progesterone-embedded silicone bands. The disadvantage of nondegradable polymer inserts is to require for disposal of these bands after their use. The study currently focuses on preparation of biodegradable progesterone-incorporated nanofiber for estrus synchronization. Three different concentrations (1.2, 1.9, and 2.5 g) of progesterone-impregnated nanofibers were fabricated using electrospinning. The spun membrane were characterized by scanning electron microscopy, X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and Fourier transform infrared spectroscopy. Uniform surface morphology, narrow size distribution, and interaction between progesterone and zein were confirmed by SEM. FTIR spectroscopy indicated miscibility and interaction between zein and progesterone. X-ray analysis indicated that the size of zein crystallites increased with progesterone content in nanofibers. Significant differences in thermal behavior of progesterone-impregnated nanofiber were observed by DSC. Cell viability studies of progesterone-loaded nanofiber were examined using MTT assay. In vitro release experiment is to identify the suitable progesterone concentration for estrus synchronization. This study confirms that progesterone-impregnated nanofibers are an ideal vehicle for progesterone delivery for estrus synchronization of bovines.ArticleItem Open Access Fabrication of Progesterone-Loaded Nanofibers for the Drug Delivery Applications in Bovine(2017) Karuppannan, Chitra; Sivaraj, Mehnath; Ganesh Kumar, J; Seerangan, Rangasamy; Balasubramanian, S; Gopal, Dhinakar Raj; TANUVASProgesterone is a potent drug for synchronization of the estrus and ovulation cycles in bovine. At present, the estrus cycle of bovine is controlled by the insertion of progesteroneembedded silicone bands. The disadvantage of nondegradable polymer inserts is to require for disposal of these bands after their use The study currently focuses on preparation of biodegradable progesteroneincorporated nanofiber for estrus synchronization. Three different concentrations (i.2, 1.9, and 2.5 g) of progesterone-impregnated nanofibers were fabricated using electrospinning. The spun membrane were characterized by scanning electron microscopy.ArticleItem Open Access Morphometry of Feline Adipose Tissue Derived Mesenchymal Stem Cells in Culture(Pashupati Foundation India, 2018-12) Nissar, Shazia; Ramesh, Geetha; Kannan, TA; Basha, Sabiha Hayath; Arunmozhi, N; Seerangan, Rangasamy; Dar, Shahid Hussain; TANUVASMorphometric analysis of feline adipose derived mesenchymal stem cells (fAD-MSCs) was done at P1 and P2 (24 and 48 hours) of culture expanded using cover slip culture technique to record the morphometric details. In all the culture, spindle cells with long thin cytoplasmic processes were found to be more in number. The measure of length and width of cell and length and width of nucleus was done. There were no significant differences in both length and width of the cell and length and width of the nucleus between 24 and 48 hours of culture condition in P1 and P2.