Browsing by Author "Mathuram, LN"
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ArticleItem Open Access ANTI-PROLIFERATIVE ACTIVITY OF TINOSPORA CORDIFOLIA DETERMINED BY CELL COUNT AND TRYPAN BLUE DYE EXCLUSION METHOD IN MCF-7 CELLS(2013) Sakthi Priya, M; Venkataramanan, KV; Mathuram, LN; Parthiban, M; Vijayanand, T; TANUVASAn in-vitro study was performed in mammary tumor cell line MCF-7 to find out the antiproliferative activity of aqueous and hydro-alcoholic extracts of Guduchi Tinospora cordifolia, each at three different doses viz., 200μg/ml, 400μg/ml and 600μg/ml. Their effects on the proliferation of cells were analyzed by cell count assay and cell viability was detected by using trypan blue dye exclusion method. Both of the extracts produced significant decrease in cell count and cell viability, with maximum effect being noticed at the dose level of 600μg/ml. This result suggest that aqueous and hydro-alcoholic extracts of Tinospora cordifolia could reduce cell count and cell viability in MCF-7 cell line and act as effective anti-proliferative agent in mammary tumor.ArticleItem Open Access Anticancer activity of Tinospora cordifolia in MCF-7 cells detected using MTT assay(2012-04) Sakthi Priya, M; Venkateswaran, KV; Mathuram, LN; TANUVASThe present study was taken up to explore the anticancer effect of aqueous and hydro-alcoholic extracts of Tinospora cordifolia in vitro, in mammary tumour cell line MCF-7 each at three different doses viz., 200 μg/ml, 400 μg/ml and 600 μg/ml and their influence on cell viability was detected using MTT assay. Both the extracts produced significant reduction in cell viability, with maximum effect being noticed at the dose level of 600 μg/ml. This result suggest that aqueous and hydro-alcoholic extracts of Tinospora cordifolia could suppress cell viability in MCF-7 cell line and act as effective natural anticancer agent in mammary tumour.ArticleItem Open Access A PRELIMINARY REPORT ON THE EFEECTS, OF CROTALARIA JUNCEA ON REPRODUCTION(1981) Gopalan, S; Mathuram, LN; Natarajan, R; TANUVASThe effect of oral administration of powdered seeds of Cr.otalaria juncea on the reproductive perfarmance in m ice was studied. It was found that it did. not, affect male fertility but effectively prevented conception in treated female mice.ArticleItem Open Access STUDIES ON THE HYPOGLYCAEMIC EFFECTS OF STRYCHNOS POTATORUM AND ACACIA ARABICA ON ALLOXAN DIABETES IN RABBITS(1981) Mathuram, LN; Samanna, HC; Ramaswamy, VM; Natarajan, R; TANUVAS1. Effect of Strychnos potatroum, Acacia arabica and tolbutamide were studied in rabbits rendered diabetic by intravenous administration of alloxan at a dose rate of 120mg./Kg body weight. 2. On the seventh day after alloxan administration, Strychnos potatorum seed powder (0.5gm.jkg), Acacia arabica bark decoction (20 ml/Kg) and tolbutamide (Rastinon 0.25gm/Kg) were administered by stomach tube to diabetic rabbits fasted for 18 hours. Blood samples were collected at 0, 1, 2, 3, and 4 hours. 3. Strychnos potatorum, Acacia arabica and tolbutamide produced significant reduction in blood glucose level as compared to the control, maximum reduction being two hours after administration. In the first hour Strychnos potatorum produced a rise in blood sugar level and subsequently a fall below the initial level.