Browsing by Author "Malik, Jitendra Kumar"
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ArticleItem Open Access Concentrations of Lead and Endosulfan on Certain Biochemical Parameters in Wistar Rats(2016-06) Ranganathan, V.; Malik, Jitendra Kumar; Babu, Naraharisetti Suresh; Aggarwal, Manoj; Rao, G.S.; Sankar, P.; TANUVASThe effect of concurrent repeated exposure of higher concentrations of lead and endosulfan were evaluated on certain biochemical parameters in male wistar rats. Rats of group I served as untreated control where as Group II received drinking water containing lead as lead acetate @1000 ppm (Pb1000). Group III was exposed to feed containing technical grade endosulfan @ 10 ppm (E100). Group IV was exposed to Pb (1000) +E (100). Blood and target organs were collected for estimation of biochemical parameters to assess toxicity by combination of these two chemicals at higher doses. The results suggest that higher doses of endoulfan and lead alone and in combination may modify general biochemical parameters carried out in the study.ArticleItem Open Access Effect Of Concurrent Exposure Of Lower Concentrations Of Lead And Endosulfan On General Biochemical Parameters In Wistar Rats(2016-06) Ranganathan, V.; Malik, Jitendra Kumar; Babu, Naraharisetti Suresh; Aggarwal, Manoj; Rao, G.S.; Sankar, P.; TANUVASThe effect of concurrent repeated exposure of lower concentrations of lead and endosulfan were evaluated on general biochemical parameters in male wistar rats. Rats of group I served as untreated control where as Group II received drinking water containing lead as lead acetate @100 ppm (Pb100). Group III was exposed to feed containing technical grade endosulfan @ 10 ppm (E10). Group IV was exposed to Pb (100) +E (10). Blood and target organs were collected for estimation of general biochemical parameters to assess toxicity by combination of these two chemicals at lower doses. The results suggest that the lower doses of endoulfan and lead alone and in combination did not change general biochemical parameters carried out in the study.ArticleItem Open Access Effect of Concurrent Exposure of Lower Concentrations of Lead and Endosulfan on Hepatic Drug Metabolizing Enzymes in Male Rats(2016-04) Ranganathan, V.; Malik, Jitendra Kumar; Babu, Naraharisetti Suresh; Aggarwa, Manoj; Rao, G.S.; Sankar, P.; TANUVASThe effect of concurrent repeated exposure of lower concentrations of lead and endosulfan were evaluated on hepatic drug metabolizing enzymes in male rats. Alterations were evaluated through changes in the phase I enzymes (viz. cytochrome P450 and cytochrome b5, aminopyrine N – demethylase and aniline p- hydroxylase) activity and phase II enzymes (viz. microsomal and cytosolic glutathione-S-transferase UDP-glucuronosyl transferase) activity in liver. Lead, when given alone at the dose of 100 ppm in drinking water and endosufan, when given alone at the dose of 10 ppm in feed, and given in combination did not change the activities of cytochrome b5, aminopyrine N – demethylase and aniline phydroxylase. When given in lower dose combination, they significantly inhibited levels of cytochrome 450, microsomal, cytosolic glutathione-S transferase and microsomal protein as compared to control and their single compounds when given alone. This study suggested that activities of xenobiotic drug metabolizing enzymes by repeated exposure to lead and endosulfan at the concentrations used in the study were not modified to produce significant toxicity in case of combined exposure.