Browsing by Author "Gogoi, Jayashree"
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ArticleItem Open Access Assessment of Role of Hepcidin in Inflammatory Condition in Canine Pyometra(Pashupati Foundation India, 2019-02) Leela, V; Gogoi, Jayashree; Rajamanickam, K; TANUVASHepcidin is one of the great discovery in hematology, associated with iron homeostasis. It is a peptide of 25 amino acids and it is synthesized primarily in the liver, which has its synthesis linked to infections and inflammations. Pyometra is a common reproductive disorder in the middle-aged bitches in diestrual phase of estrous cycle when uterus is being exposed to high levels of progesterone. Pyometra is associated with bacterial infection leading to endometritis and toxaemia. Pyometra develops as a result of complex etiological factors which includes hormonal influence of uterine environment, virulence of the infecting bacteria with concomitant disability of the bitches to combat the infection or its inflammatory products. This accelerates the inflammatory process in the affected bitches and activates the macrophages to scavenge the pathogenic bacteria. The present study was conducted to explore the role of hepcidin hormone in mediating the inflammatory process in pyometra affected bitches. Blood samples were collected from ten dogs with open type of pyometra and from ten apparently healthy dogs. Haematological parameters and hepcidin were estimated in pyometra affected bitches and in control animals. Leucocytosis and neutrophilia and their blood hepcidin hormone level were elevated when compared to apparently healthy dogs. This shows that increase in hepcidin hormone is beneficial in mediating the inflammatory process because it increases the intracellular iron content of macrophages which is needed for destruction of engulfed pathogens.ArticleItem Open Access Collagen - A Bounteous Animal Protein for the New Era of Wound Treatment(Academy for Environ. and Life Sci., 2017-10) Rajamanickam, K.; Gogoi, Jayashree; Leela, V.; Gowrishankar, S.; TANUVASThe whole animal kingdom is bestowed with u protein named as collagen. With human ingenuity this abundant protein is made into well orgonized, three dimensional scaffolds those are nontoxic, biodegradable and biocompatible on exogenous usage.ArticleItem Open Access Current and Future Prospects of Colostrum - Indian Ethnic Food Supplement(2016) Rajamanickam, K.; Gogoi, Jayashree; Leela, V.; Suganya, G.; TANUVASArticleItem Open Access Effect of ovariohysterectomy on oxidative stress markers in pyometra affected bitches(2018) Gogoi, Jayashree; Leela, V.; Suganya, G.; Shafiuzama, M.; Vairamuthu, S.; Rajamanickam, K.; Pandiyan, A. Serma Saravana; TANUVASCanine pyometra has been studied extensively in the past few decades to find the causes and prognostic markers associated with this infective disease of intact bitches.ThesisItem Open Access ENDOCRINE AND BIOCHEMICAL CHANGES IN PYOMETRA IN BITCHES(2018) Gogoi, Jayashree; Leela, V; Suganya, G; Shafiuzama, Mohamed; Vairamuthu, S; TANUVASCanine pyometra has been studied extensively in the past few decades to findthe causes and prognostic markers associated with this infective disease of intact bitches, whichis known to cause a systemic inflammatory responses leading to multiple systemicdysfunctions. Besides the well described clinical symptoms andsystemic effects of this disease, limited research on acute phase proteins, antioxidativestatus and lipid peroxidation profile of this condition was done, although hormonal effects have been repeatedly investigated to determine the exact pathophysiology of the disease. In the present study,the changes in hormonal assay, acute phase proteins, antioxidative status and lipid peroxidation of the pyometra affected bitches both pre-operatively and post-operatively till 14days of ovariohysterectomy was studied.ArticleItem Open Access Morphological ldentification of Rumen Protozoal Population in Domestic Ruminants of Chennai(2018) Gogoi, Jayashree; Rajamanickam, K.; Leela, V.; TANUVAS