Browsing by Author "BASAVARAJ S BHAJANTRI"
Now showing 1 - 1 of 1
Results Per Page
Sort Options
ThesisItem Open Access “STUDY ON PATHOGENICITY OF DICLOFENAC SODIUM ON SWISS ALBINO MICE (Mus musculus)”(Anand Agricultural University, Anand, 2009) BASAVARAJ S BHAJANTRI; Dr. K. S. PrajapatiThe present research work was conducted on 24 male and 24 female Swiss albino mice to study the repeated dose toxicity of Diclofenac sodium. Animals were randomly divided into 4 different groups with six male and six female in each. Group I severed as control. Group II, III and IV were administered with 2.37, 4.75 and 9.5 mg/kg of Diclofenac sodium per kg body weight respectively once daily for 28 days. The animals were monitored for any observable toxic symptoms and mortality throughout the experimental period. All the animals were weighed weekly to monitor body weight gain. The food consumption was also measured once a week. After completion of 28 days treatment, blood samples were collected for haematology and serum biochemical analysis. Necropsy was performed in all sacrificed animals and gross lesions were recorded. Tissue samples were collected in 10% formalin solution for histopathological examination.