“STUDY ON PATHOGENICITY OF DICLOFENAC SODIUM ON SWISS ALBINO MICE (Mus musculus)”
Loading...
Date
2009
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Anand Agricultural University, Anand
Abstract
The present research work was conducted on 24 male and 24 female Swiss albino
mice to study the repeated dose toxicity of Diclofenac sodium. Animals were randomly
divided into 4 different groups with six male and six female in each. Group I severed as
control. Group II, III and IV were administered with 2.37, 4.75 and 9.5 mg/kg of
Diclofenac sodium per kg body weight respectively once daily for 28 days. The animals
were monitored for any observable toxic symptoms and mortality throughout the
experimental period. All the animals were weighed weekly to monitor body weight gain.
The food consumption was also measured once a week. After completion of 28 days
treatment, blood samples were collected for haematology and serum biochemical
analysis. Necropsy was performed in all sacrificed animals and gross lesions were
recorded. Tissue samples were collected in 10% formalin solution for histopathological
examination.
Description
Keywords
Veterinary Pathology, Studies