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ArticleItem Open Access Effect of Cigarette Smoke on Rats under Hypobaric Condition(Tamil Nadu Veterinary and Animal Sciences University, 2003-10) Vasudevan, B.; Abbas, K. Zaheer; Nayeem, Md.; TANUVASThirty Wistar rats of either sex were randomly distributed to three groups, each consisting of 10 animals. Group I served as sea level control. Group II was exposed to simulated hypobaric condition at 8000 ft. for six hours per day for 15 days. Group III was exposed to one standard non-filtered cigarette smoke per day under hypobaric condition. There was significant decrease in the weight of lung (P<0.01) in groups II and III and kidneys (P<0.05) in group III, whereas Hb and TEC levels showed significant (P<0.01) increase in both these groups. Microscopically, in addition to the emphysema, interstitial thickening of alveoli of group II rat lungs, multifocal necrosis and granuloma formation in the lung and increased goblet cell activity, loss of cilia and desquamation in the bronchi were observed in group III. The study indicated that even a short exposure to cigarette smoke would cause deleterious effect in lungs in unacclimatized rats.