STUDIES ON RENOPROTECTIVE EFFECT OF AQUEOUS AND ALCOHOLIC BIHERBAL EXTRACTS OF Vigna unguiculata AND Hordeum vulgare IN WISTAR RATS
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Date
2018
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DEPARTMENT OF VETERINARY MEDICINE COLLEGE OF VETERINARY SCIENCE AND ANIMAL HUSBANDRY ANAND AGRICULTURAL UNIVERSITY ANAND
Abstract
The present study was conducted to evaluate the renoprotective effect of aqueous, alcoholic and biherbal seed extracts of Vigna unguiculata (V.U.) and Hordeum vulgare (H.V.) on 86 adult healthy female Wistar rats (12-15 weeks of age). Rats were divided in to 14 groups- I (lithiatic control), II (vehicle control), III (Aqueous extract-AQ. EX. of V.U., low dose), IV (AQ. EX. of V.U., high dose), V (Alcoholic extract-AL. EX. of V.U., low dose), VI (AL. EX. of V.U., high dose), VII (AQ. EX. of H.V., low dose), VIII (AQ. EX. of H.V., high dose), IX (AL. EX. of H.V., low dose), X (AL. EX. of H.V., high dose), XI (Biherbal-BIH. AQ. EX., 1:1, low dose), XII (BIH. AQ. EX., 1:1, high dose), XIII (BIH. AL. EX., 1:1, low dose) and XIV (BIH. AL. EX., 1:1, high dose). All groups had six rats each. Group I had eight rats. All the rats were numbered group wise and individually. Group II was given 0.5% sodium bicarbonate. Urolithiasis was induced in group I and III to XIV animals using 0.75 % (v/v) ethylene glycol and 2% (w/v) ammonium chloride along with drinking water as stone inducing agent for 28 days. After 28th day, groups III to XIV were given AQ., AL. and BIH. seed EX. of V.U. and H.V.
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