STUDIES ON PHARMACOKINETICS AND SAFETY OF GEMIFLOXACIN ALONE AND WITH PIPERINE IN LAYER BIRDS
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Date
2018
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COLLEGE OF VETERINARY SCIENCE AND ANIMAL HUSBANDRY ANAND AGRICULTURAL UNIVERSITY ANAND
Abstract
Gemifloxacin, a fourth-generation synthetic broad spectrum fluoroquinolone
has bactericidal action against broad range of bacteria including those that are
resistant to conventional antimicrobial drugs. Piperine, the major plant alkaloid
present in pepper, is reported to have bioavailability-enhancing activity for nutritional
substances and drugs. Despite the great potential for clinical use of gemifloxacin and
beneficial (bioenhancing) effect of piperine on pharmacokinetics of various
antimicrobials, the data on pharmacokinetics and safety profile of gemifloxacin and
piperine alone as well as with each other in layer birds are not available. Looking to
these overall points, the present study was conducted in layer birds to investigate
pharmacokinetics of gemifloxacin and piperine alone and in combination with each
other at 10 mg/kg dose rate following intravenous and oral administration as well as
safety of both drugs alone and together at same dose rate by daily oral administration
for 5 days. Liquid chromatography with mass spectrometry (LC-MS/MS) method was
developed and validated for the simultaneous estimation of gemifloxacin and piperine
concentration in plasma samples of the present pharmacokinetics study in layer birds.
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