STUDIES ON PHARMACOKINETICS AND SAFETY OF CIPROFLOXACIN IN COW CALVES

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dc.contributor.advisorVerma, M. P.
dc.contributor.authorBHAVSAR, S. K.
dc.date.accessioned2018-07-02T12:52:25Z
dc.date.available2018-07-02T12:52:25Z
dc.date.issued2000
dc.description.abstractThe present study was conducted to determine the pharmacokinetics of ciprofloxacin after single dose intravenous, intramuscular or subcutaneous administration and multiple-dose intravenous administration. Additionally safety of multiple intravenous doses was evaluated. Following single dose (5 mg/kg of body weight) and multiple-dose (5 mg/kg of body weight repeated at twelve hour intervals for two and five days) intravenous administration of ciprofloxacin, the therapeutically effective serum ciprofloxacin concentration (> 0.12 µg.ml-1) was maintained for up to 8 hours. The pharmacokinetics of the drug was best described by two-compartment open model following the single and multiple-dose intravenous administration of ciprofloxacin. The drug was widely distributed (Vd area; 1.99 ± 0.07 1 kg-1) and rapidly eliminated (t1/2β; 1.69 ± 0.12 hours) following intravenous administration. The drug was not detectable 12 hours after the fourth or tenth intravenous doses given at the rate of 5 mg/kg of body weight in calves. Single and multiple-dose pharmacokinetics of the drug were found to be identical. Following single-dose administration at the rate of 5 mg/kg of body weight, therapeutically effective serum ciprofloxacin concentration was detectable at 2 minutes after intravenous and intramuscular administration and at 8 minutes after subcutaneous administration, However, the concentration was maintained for longer time after subcutaneous administration (12 hours) than following intramuscular administration (8 hours).en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810056485
dc.keywordsSTUDIES ON PHARMACOKINETICS, SAFETY OF CIPROFLOXACIN, COW CALVESen_US
dc.language.isoenen_US
dc.publisherAAU, Ananden_US
dc.research.problemSTUDIES ON PHARMACOKINETICS AND SAFETY OF CIPROFLOXACIN IN COW CALVESen_US
dc.subVeterinary Pharmacologyen_US
dc.subjectVETERINARY PHARMACOLOGYen_US
dc.subjectA STUDYen_US
dc.themeSTUDIES ON PHARMACOKINETICS AND SAFETY OF CIPROFLOXACIN IN COW CALVESen_US
dc.these.typePh.Den_US
dc.titleSTUDIES ON PHARMACOKINETICS AND SAFETY OF CIPROFLOXACIN IN COW CALVESen_US
dc.typeThesisen_US
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