STUDIES ON PHARMACOKINETICS, BIOAVAILABILITY AND SAFETY OF KETOPROFEN IN COW CALVES
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Date
2008
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Publisher
Anand Agricultural University
Abstract
Ketoprofen is a non steroidal anti-inflammatory drug (NSAID) used for its anti-inflammatory, analgesic and antipyretic properties in Veterinary medicine. The pharmacokinetics of ketoprofen after its single dose intravenous and intramuscular administration was investigated in six crossbred cow calves by non compartmental approach. The drug was administered at the dose rate of 3.0 mg.kg-1 body weight and assayed in plasma by HPLC analysis. The present study also evaluated safety of ketoprofen (3.0 mg.kg-1) after repeated administration at 24 h interval for 5 days in calves
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Keywords
Veterinary Pharmacology, Study