Synthesis of halogenated chalcones and their antifungal evaluation

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dc.contributor.advisorSidhu, Anjali
dc.contributor.authorSarao, Navjot Singh
dc.date.accessioned2017-12-04T12:24:38Z
dc.date.available2017-12-04T12:24:38Z
dc.date.issued2017
dc.description.abstractChalcone is a generic term used to describe compounds with the 1,3-diphenylprop-2-en-1-one framework. On synthetic ground, chalcones are synthesized by Claisen-Schmidt condensation reaction which involved the base mediated reaction of andifferent aldehydeswith different ketone in presence of strong bases like sodium hydroxide and potassium hydroxide. In the present study, series of novel halogenated chalcones (1-14) were synthesized through ClaisenSchmidt condensation reaction between different halogenated aldehydes and α, β-unsaturated halogenated ketonesunder basic conditions. The synthesized compounds were formulated as nano aqua emulsions using oleic acid as oil phase with Tween 20 as surfactant,under ultrasonic irradiation. Antifungal activity of prepared chalcone nanoemulsions was tested against various phytopathogenic fungi viz. Pyriculriagrisea, Dreschslera oryzae, Colletotrichum falcatum and Ustilago hordei. The results indicated that the various synthesized halogenated chalcones showed mild activity against various fungi.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810036886
dc.keywordsAldehydes, acetophenones, halogenated chalcones, Pyriculriagrisea, Dreschslera oryzae, Colletotrichum falcatum, Ustilagohordeien_US
dc.language.isoenen_US
dc.pages51en_US
dc.publisherPunjab Agricultural University, Ludhianaen_US
dc.research.problemSynthesis of halogenated chalcones and their antifungal evaluationen_US
dc.subChemistryen_US
dc.subjectnullen_US
dc.themeSynthesis of halogenated chalcones and their antifungal evaluationen_US
dc.these.typeM.Scen_US
dc.titleSynthesis of halogenated chalcones and their antifungal evaluationen_US
dc.typeThesisen_US
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