AUTOLOGOUS PLATELET RICH PLASMA FOR THE TREATMENT OF CANINE SUPERFICIAL CORNEAL ULCERS: A COMPARISON BETWEEN SUBCONJUNCTIVAL AND TOPICAL APPLICATIONS
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Date
2022-12-20
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COLLEGE OF VETERINARY AND ANIMAL SCIENCES MANNUTHY, THRISSUR, KERALA VETERINARY AND ANIMAL SCIENCES UNIVERSITY
Abstract
Comparative evaluation of autologous platelet rich plasma as topical and subconjunctival injection for the treatment of canine superficial corneal ulcers was conducted in Teaching Veterinary Clinical Complex, Mannuthy and University Veterinary Hospital, Kokkalai. A total of twelve animals with both superficial epithelial and superficial stromal ulcers were selected for the study. They were randomly divided into two groups of six animals each. Signalment and detailed anamnesis of the selected cases were recorded on the day of presentation. Clinical,ophthalmic and neuro-ophthalmic examinations of the animals were carried out on day of presentation and on day 7, 14, 21 and 28. Platelet rich plasma was prepared from venous blood of the selected animals with EDTA as the anticoagulant, through double centrifugation – modified syringe method. In group I, the PRP was applied topically as drops twice daily for seven days and in group II, PRP administered as superior bulbar subconjunctival injection. Among the selected cases, theanimals with superficial epithelial ulcer obtained complete corneal clarity in both groups. Animals with superficial stromal ulcers had retained a scar on the 28th day in both groups. On day 7 all the animals except one in both groups were negative for fluorescein dye test. From 14 day onwards all the animals were completely negative for fluorescein dye test. Corneal oedema and vascularisation disappeared earlier in group II compared to group I. The efficacy of PRP injection through subconjunctival route was found to be superior than the topical application in the present study. The PRP treatment was effective for faster superficial corneal ulcer healing
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AUTOLOGOUS PLATELET RICH PLASMA FOR THE TREATMENT OF CANINE SUPERFICIAL CORNEAL ULCERS: A COMPARISON BETWEEN SUBCONJUNCTIVAL AND TOPICAL APPLICATIONS, AUTOLOGOUS PLATELET RICH PLASMA, SUPERFICIAL CORNEAL ULCERS