HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECT OF Aloe vera L. IN NON-INSULIN DEPENDENT DIABETICS
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Date
2010
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PAU Ludhiana
Abstract
Ninety non-insulin dependent diabetic subjects were selected from Punjab Agricultural
University and Civil hospitals of Ludhiana. The selected subjects were divided into three
groups viz. Group I, II and III having thirty subjects each. The subjects of group I was not
given any treatment. The subjects of group II and III were supplemented with 100 mg and 200
mg of Aloe vera L. gel powder respectively for a period of three months and supplementation
was continued along with nutrition counselling for the next three months. The nutrition
education was given for three months after fifteen days interval to the subjects of group II and
III through individual and group contact and gain in nutrition knowledge was assessed after
the study. General information, diabetic information, and dietary pattern of the subjects were
recorded. The blood glucose and lipid profile were analyzed. The anthropometric
measurements and blood pressure of the subjects was also measured. Significant improvement
was seen in the food habits, physical activity, sleeping pattern and dietary pattern of the
subjects of group II and III after the study. The mean daily intake of green leafy vegetables,
other vegetables, fruits increased significantly (P≤0.01) in the subjects of group II and III and
a non significant increase (P≤0.01) was seen in the subjects of group I. The mean energy,
carbohydrates, protein and fat intake decreased significantly (P≤0.01) in the subjects of group
II and III and a non significant decrease (P≤0.01) was seen in the subjects of group I. It was
seen that there was a significant (P≤0.01) reduction in fasting blood glucose level by 11.4 %
and 15.4 % and post prandial glucose level 18.5 % and 27.8 % in the subjects of group II and
III respectively after the study. Significant (p≤0.01) reduction in total cholesterol 8.6 % and
10.1 %, triglycerides 9.6% and 12.2 %, LDL-C 12.8 % and 14.6 %, VLDL-C 9.6 % and 12.2
% and an increase in HDL-C 7.3 and 9.4 percent was observed in the subjects of group II and
III respectively. The ratio of total cholesterol to HDL-C reduced from 5.68 to 4.83 and 6.15 to
5.00 and LDL-C to HDL-C from 3.74 to 3.03 and 4.12 to 3.18 in the subjects of group II and
III respectively after the study. There was also a significant decrease (P≤0.01) in the blood
pressure of the subjects in group II and III and a non significant decrease (P≤0.01) was seen in
the subjects of group I. There was a significant increase (P≤0.01) in knowledge, attitude and
practice scores obtained by the subjects of group II and III and a non significant increase
(P≤0.01) was seen in the subjects of group I. Hence it can be inferred from the results that
supplementation of Aloe vera L. gel powder along with nutrition counselling significantly
improved the nutritional status of the diabetic patients.
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