STUDIES ON PHARMACOKINETICS AND SAFETY OF GEMIFLOXACIN IN BROILER BIRDS
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Date
2017
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Department of Veterinary Pharmacology and Toxicology College of Veterinary Science and Animal Husbandry Anand Agricultural University Anand
Abstract
Gemifloxacin is a newer, fourth-generation fluoroquinolone drug that exhibits broad spectrum of antibacterial activity than the older fluoroquinolones. The present study was designed to investigate the detailed pharmacokinetics of gemifloxacin in broiler birds following single dose intravenous, intramuscular and oral administration at the rate of 10 mg/kg of body weight and also evaluate safety of repeated oral administration of gemifloxacin at a dose of 10 mg/kg of body weight for five days in broiler birds was also studied by monitoring heamatology and blood biochemistry parameters. Drug concentration in plasma was determined using High Performance Liquid Chromatography (HPLC). Pharmacokinetic parameters were calculated using non-compartmental approach.
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