Effect Of Procaine And Antipyrine On The Pharmacokinetics Of Diminazene In Buffalo Calves
| dc.contributor.advisor | Srivastava, A. K. | |
| dc.contributor.author | Kaur, Jaspreet | |
| dc.date.accessioned | 2019-02-28T05:15:09Z | |
| dc.date.available | 2019-02-28T05:15:09Z | |
| dc.date.issued | 2000 | |
| dc.description.abstract | The present study was planned to investigate the effect of procaine and antipyrine on the pharmacokinetics, urinary excretion and dosage regimen of diminazene in buffalo calves. In addition, in vitro erythrocytic partitioning and plasma protein binding of diminazene were also studied. Diminazene was administered at the dose rate of 3.5 mg.kg-1 along with procaine (0.2 mg.kg-1) and antipyrine (4.16 mg.kg-1) by single intramuscular route in healthy buffalo calves in two different dosage forms i.e. granules and suspension. The heparinized blood samples were collected at various predetermined time intervals and diminazene was estimated by diazotization method. After i.m. administration of granular form of diminazene, appreciable concentration (1.53 ± 0.15 ?g.m1-1) appeared at 1 min and the drug was detected upto 7 days (1.05 ± 0.11 ?g.m1-1). Similarly following administration of suspension form, plasma level at 1 min was (1.50± 0.07 ?g.m1-1) and at the end of 7 days it was (1.25 ± 0.10 pg.m1-1). On comparing the results of various pharmacokinetic parameters of both forms of diminazene, it was revealed that there was no significant difference in most of the pharmacokinetic parameters. The values of t05Ka, t0.5a,Vd ( ) and CITranged between 0.057-0.446 h, 0.314-0.400 h, 538.3-667.6 h,2.11-2.70 L.kg-1 and 3.49-3.66 ml.kg-1.11-1, respectively. For evaluating the effect of procaine and antipyrine on pharmacokinetics of diminazene, the data of present investigation was compared with already established data following alone administration of diminazene. The results revealed that procaine and antipyrine causes slow elimination of diminazene from body (as the t053 was increased to 8-10 folds) and prolongs the therapeutic effect of diminazene in body for more than 20 days. Diminazene bound to plasma proteins to the extent of 34.0 ± 1.40 per cent. At various blood concentrations ranging from 1.25 to 20 ilg.m1-1, the erythrocytic partitioning was 23.6 ± 3.25 per cent. The appropriate dosage regimen of diminazene in buffalo calves when administered along with procaine and antipyrine would be 4.3 mg.kg-4 followed by 1.9 mg.kg at 15 days interval. | |
| dc.identifier.uri | http://krishikosh.egranth.ac.in/handle/1/5810097386 | |
| dc.language.iso | en_us | |
| dc.publisher | Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana | |
| dc.sub | Veterinary Pharmacology and Toxicology | |
| dc.these.type | M.V.Sc. | |
| dc.title | Effect Of Procaine And Antipyrine On The Pharmacokinetics Of Diminazene In Buffalo Calves | |
| dc.type | Thesis |
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