Synthesis of hybrid benzimidazoles-metal sulfide nanoformulations as antifungal agents

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dc.contributor.advisorAnjali
dc.contributor.authorRadha Rani
dc.date.accessioned2020-05-28T07:48:30Z
dc.date.available2020-05-28T07:48:30Z
dc.date.issued2020
dc.description.abstractThree samples of MS-NSs viz. CuS-NSs, FeS-NSs and MnS-NSs were prepared using sonochemical mediated reaction. Co-precipitation method produced three samples of MSNRs viz. CuS-NRs, FeS-NRs and MnS-NRs in solid form. Statistical analysis of antifungal potential of MS-NPs against phytopathogenic fungi of rice viz. D. oryzae, F. verticillioides, C. lunata and S. oryzae indicated that CuS-NSs exhibited the best antifungal potential. A series of 32 compounds containing benzimidazole and 1,2,4-triazole, in a single molecule, were designed using variety of spacers between the two bioactive moieties. Only four compounds viz. 1, 4, 5 and 8 were chosen for synthesis following the combined criteria of stronger binding to tubulin and lanosterol 14 -demethylase (with docking score -5.9 and - 8.9Kcal/mol, respectively), Lipinski filtrations, FMO approach and Toxtree analysis. Compound 8 (4-(1H-benzo[d]imidazol-2-yl)-2-methoxyphenyl 2-(1H-1, 2, 4-triazol-1- ylamino) acetate) was found to be the best antifungal compound against all the test fungi (ED50 16 μg/ml). U-CuS-NSs underwent in situ surface modification, via organic coating with most active benzimidazolyl-1,2,4-triazole i.e compound 8 to produce their nanohybrid (NH-CuS-8). Comparison of ED50 values led to the conclusion that hybridization of CuS-NSs with compound 8 worked well in enhancing antifungal potential of CuS-NSs against all test fungi. Priming the seeds with solutions of FeS-NSs and MnS-NSs resulted in improved seed health but CuS-NSs had negative impact. Seed treatment evaluation studies revealed great potential of NH-CuS-8 to reduce fungal infection.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810146608
dc.keywordsMetal sulfide nanoparticles, benzimidazole, 1,2,4-triazole, nanohybrid, antifungalen_US
dc.language.isoenen_US
dc.pages111en_US
dc.publisherPunjab Agricultural University, Ludhianaen_US
dc.research.problemSynthesis of hybrid benzimidazoles-metal sulfide nanoformulations as antifungal agentsen_US
dc.subChemistryen_US
dc.themeSynthesis of hybrid benzimidazoles-metal sulfide nanoformulations as antifungal agentsen_US
dc.these.typePh.Den_US
dc.titleSynthesis of hybrid benzimidazoles-metal sulfide nanoformulations as antifungal agentsen_US
dc.typeThesisen_US
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