Hypoglycaemic effect of Brassica Juncea (mustard) and Trigonella Foenum-graecum (fenugreek) in albino rats
dc.contributor.advisor | Aravindakshan, C M | |
dc.contributor.author | Preethy, John | |
dc.contributor.author | KAU | |
dc.date.accessioned | 2019-05-25T10:46:30Z | |
dc.date.available | 2019-05-25T10:46:30Z | |
dc.date.issued | 2003 | |
dc.description | PG | en_US |
dc.description.abstract | A study was undertaken to assess the hypoglycaemic activity of seed powders of Brassica juncea (mustard) and Trigonella foenum-graecum (fenugreek) at two different doses (2g/kg and 8g/kg body weight) in alloxan diabetic rats and to compare their efficacy with standard oral hypoglycaemic drug, glibenclamide. The experiment was conducted in fifty six male albino rats for a period of 45 days. Rats were divided into seven groups of eight each. Group I served as normal control and group 11 as diabetic control. Seed powders of mustard and fenugreek at low and high doses were given to group III to group VI respectively for 30 days from 16th day onwards. Glibenclamide at a rate of 0.5mg/ animal/day was fed to group VII. Blood glucose level was estimated at zero day, 16th day and 45th day of the experiment. Serum cholesterol, serum triglyceride and liver glycogen were estimated at 45th day of the experiment. Fenugreek seed powder caused a maximum decrease (39.14 percent) in blood glucose level at 8g/kg body weight. But it is not effective as glibenclamide which caused a 46.38 percent reduction. At 2g/kg body weight, fenugreek caused 21.18 percent reduction. Mustard at 8g/kg can also act as a hypoglycaemic agent, hut less effective when compared to fenugreek seed powder. No significant reduction was noticed with the low dose of mustard. This showed that fenugreek seed powder at both doses and mustard at high dose are having potent hypoglycaemic effect. Higher level of serum cholesterol and triglyceride were noticed in group II ie, 166.96±15.70 mg% and 162.08± 25.04 mg% respectively. The levels of group III animals were comparable to group n. All the other treatment groups showed a significant reduction in serum cholesterol and triglyceride levels. But the reduction is not as effective as that caused by glibenclamide. Fenugreek seed powder showed a better hypolipidaemic effect than mustard seed powder. Low level of liver glycogen was observed in group n. Among the treatment groups, group VII showed a peak level of liver glycogen. The liver glycogen level of group VI was comparable to that of group VII ie, 2.16± 0.05 g% and 2.17± 0.05 g%. respectively. Other treatment groups also showed an increase in liver glycogen. From the study, it can be concluded that fenugreek seed powder at both doses and mustard seed powder at high dose are potent hypoglycaemic agents, but their effect is less when compared to glibenclamide. | en_US |
dc.identifier.uri | http://krishikosh.egranth.ac.in/handle/1/5810104618 | |
dc.keywords | Toxicology | en_US |
dc.language.iso | en | en_US |
dc.publisher | Department of Pharmacology and Toxicology, College of Veterinary and Animal Sciences, Mannuthy | en_US |
dc.sub | Veterinary Pharmacology | en_US |
dc.subject | null | en_US |
dc.theme | Hypoglycaemic effect | en_US |
dc.these.type | M.V.Sc. | en_US |
dc.title | Hypoglycaemic effect of Brassica Juncea (mustard) and Trigonella Foenum-graecum (fenugreek) in albino rats | en_US |
dc.type | Thesis | en_US |