AFLATOXIN INDUCED CYTOLOGiCAL ALTERATIONS IN DUCKS
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Date
1996
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COLLEGE OF VETERINARY AND ANIMAL SCIENCES Mannuthy - Thrissur
Abstract
An experimental study was conducted in desi ducks to
assess the cytological alteiations induced by aflatoxin B1 (AFBl)
and 4 dimethyl ainino axo benzene (4 DAB).
One hundred and eight desi ducks of one month age were
selected for tlu: study flu- birds were divided into two treatment
groups which were given AFBl ( l(bg/kg. body weight and I5^g/
kg body weight) and 4 DAlt (5 mg and 10 mg/kg. body
werght) and a control group 1 ,ach group consisted of thirty six
birds Body weigirt, haemognun, clotting time, total serum protein,
serum albumin, serum globulin, albumin-globulin ratio, serum
aspartate amino transterase, serum alanine amino transferase,
serum bilirubin and cytogenetic assay were estimated at periodic
intervals T he ducks were subjected to detailed autopsy and
histopathology.
C, linically, the experimental birds were healthy. Anaemia,
leucocytosis and increased blood clotting time were noticed in
birds which received I ^g/kg body weight of AFBl and both the
dose levels of 4 DAB Total serum protein was reduced in all the
treated birds In the aflatoxin group, serum albumin and globulin
levels weie decreased Albumin-globulin ratio was increased in
^ tieated buds Serum cuspartate amino transferase level
was elevated in birds which received lO^g/kg. body weight of
Al Bl and 10 mg/kg body weigl.t olM I/tAB Birds which received
AF B1 as well <is 10 ing/ky. body weight of 4 DAB showed an
elevation in serum alamne ammo transferase level. Serum
bilirubin was increased in all (he treated birds.
Those ducks which weie fed with ATBl at 15/^g/kg. body
weight showed tendency ol liepatoma formation during the
experiment
1 he ducks which received 5 mg/kg. body weight of 4 DAB
exhibited gitiss and histopathological lesions suggestive of
hcpatosis and mild cirrhosis. 1 he birds given 10 mg/kg. body
weight of 4 DAB revealed gross as well as histopathological
lesions of liepatic degeneration and necrosis and indications of
neoplatic changes.
Trend towards polyploidy was the major chromosomal
aberration observed in ducks which received 1 ^g/kg. body weight
of AFBl.
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