Evaluation of echocardiographic and electrocardiographic effects of tiletamine-zolazepam and ketamine-diazepam in dogs
| dc.contributor.advisor | Tiwari,Deepak Kumar | |
| dc.contributor.author | Monika Rani | |
| dc.date.accessioned | 2024-07-27T04:38:20Z | |
| dc.date.available | 2024-07-27T04:38:20Z | |
| dc.date.issued | 2023-04-13 | |
| dc.description.abstract | The present study was conducted on twelve female dogs irrespective of age, breed and body weight brought for elective ovariohysterectomy which were randomly divided into two groups comprising of six animals in each group. Pre-anaesthesia was achieved by administration of atropine sulphate @ 0.04mg/kg IM followed by butorphanol @ 0.2mg/kg b.wt IM after 10 minutes. Induction was achieved by administration of tiletamine-zolazepam @ 7.5mg/kg IV and ketamine (5mg/kg IV) - diazapam (0.5mg/kg IV) in group-I and II, respectively. All the animals underwent thorough systemic investigation protocol for recording of parameter viz., history, physiological parameters, haematology, serum biochemistry, echocardiographic indices, electrocardiography. Mean ± SE values of age were 24.17± 2.10 and 27.33 ± 2.29 months and body weight were 16.00 ± 1.88 and 14.92 ± 0.69 kgs in group I and II, respectively. Rectal temperature (o F) decreased significantly (p<0.05) in both the groups at time period TA and TR as compared to T0. Heart rate increased significantly (p<0.05) after anaesthesia (TA) in group I and and increased significantly (p<0.05) at time period TA as compared to T0 and decreased significantly (p<0.05) at time period TR as compare to TA in group II. Oxygen saturation showed decreased significantly (p<0.05) at time period TA and TR in group I and decreased significantly (p<0.05) at time period TA and increased significantly (p<0.05) at time period TR in group II. The mean values of haemoglobin, packed cell volume and TEC decreased significantly (p<0.05) at TA and TR in group I. Biochemical parameters changed non-significantly in between and within the groups. Echocardiographic Parameters LVIDd, LVIDs, IVSd, IVSs, LVPWd, LVPWs, EDV, ESV, SV, CO, EF, FS, LVET, EPSS and LA/AO changed non- significantly in between and within the groups. Doppler parameters including Peak velocity of Ewave of mitral valve significantly (p<0.05) decreased during time period TA and TS in group I and significantly (p<0.05) decreased at time period TS in group II. Peak velocity of A-wave of mitral valve in both groups were significantly (p<0.05) decrease at time period TI and TS. E and A wave ratio of mitral valve showed non-significant increase and decrease in group I and group II, respectively. Maximum aortic velocity and aortic pressure gradient showed non-significant decreased from T0 to TS in group I and group II, respectively. Electrocardiographic parameters viz. amplitude of P, QRS and T waves, duration of P wave, QRS complex, T wave forms, PR and QT intervals and ST segment changed non-significantly in between and within groups. Thus Ketamine-diazepam provides better haemodynamic and respiratory stability as compared to tiletamine-zolazepam in the dogs undergoing elective surgery. The systolic functions were normal but diastolic functions were significantly altered in both groups but the statistically significant values were within normal range. So on the basis of echocardiographic and electrocardiographic indices, it was concluded that both the anaesthetic combinations provided good cardiovascular stability in dogs. | |
| dc.identifier.uri | https://krishikosh.egranth.ac.in/handle/1/5810212529 | |
| dc.language.iso | English | |
| dc.pages | 83 + xi | |
| dc.publisher | LUVAS Hisar | |
| dc.sub | Veterinary Surgery and Radiology | |
| dc.theme | Evaluation of echocardiographic and electrocardiographic effects of tiletamine-zolazepam and ketamine-diazepam in dogs | |
| dc.these.type | M.V.Sc. | |
| dc.title | Evaluation of echocardiographic and electrocardiographic effects of tiletamine-zolazepam and ketamine-diazepam in dogs | |
| dc.type | Thesis |