STUDIES ON CHEMOPROTECTIVE ACTIVITY OF PHYLLANTHUS AMARUS ON AZASERINE INDUCED PANCREATIC CANCER IN WISTAR RATS
Loading...
Date
2014
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
AAU, Anand
Abstract
Cancer is a devastating disease with a severe impact on the physical and psychological well being of patients. Pancreatic cancer has been reported in various species of animals including dogs and cats. To date, only limited therapeutic options are available for the treatment of cancers. This leads to alternative therapies, including the holistic approach of alternative medicine, particularly preparations from herbal products, which have formed the basis for traditional medicine for thousands of years. Phyllanthus amarus is a well known plant in Ayurveda and Siddha. It has been found to have a lot of medicinal properties particularly for its anti-cancerous or chemoprotective activity. Eighty rats were selected for the experiment. They were randomly divided into eight groups. Group I served as a healthy control group consisted of healthy rats. Pancreatic cancer was induced in group II, III, IV, V and VI rats using azaserine as inducing agent. Group II rats were kept untreated as pancreatic cancer control. Group III rats were treated with aqueous extract of Phyllanthus amarus (200 mg/kg body weight) and Group IV rats were treated with aqueous extract of Phyllanthus amarus (400 mg/kg body weight). Group V rats were treated with alcoholic extract of Phyllanthus amarus (200 mg/kg body weight) and Group VI animals treated with alcoholic extract of Phyllanthus amarus (400 mg/kg body weight). Group VII and VIII rats were kept as plant extract control for studying the effect of extract on normal rats. Significant (P < 0.05) reduction in feed consumption was observed in cancer bearing rats group II (12.70 ± 0.07 g) compared to normal rats of group I (13.36 ± 0.07 g). In group IV rats treated with aqueous extract of plant, reduction in feed intake (12.98 ± 0.09 g) was observed. A non-significant reduction in body weight gain was observed in group II (46.50 ± 8.20 g) compared to normal rat group I (48.50 ± 9.04 g). Four rats of group II were found dull and depressed on 3rd week of experiment. One rat in group II showed alopecia.
Description
Keywords
VETERINARY MEDICINE, A STUDY