ANTHELMINTIC ACTIVITY OF Acorus calamus RHIZOME EXTRACT AGAINST Haemonchus SPECIES IN GOATS

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dc.contributor.advisorChangkija, Bendangla
dc.contributor.authorSHARMA, CHAMPA
dc.date.accessioned2022-06-28T08:11:43Z
dc.date.available2022-06-28T08:11:43Z
dc.date.issued2022-01
dc.description.abstractThe present investigation was carried out with the view to study the anthelminitic activity of Acorus calamus rhizome extract against Haemonchus species in goats. Haemonchus contortus worms were found to be the predominant worm in the goat population of the farm. The qualitative phytochemical analysis of hydroethanolic extract of Acorus calamus rhizome revealed the presence of terpenoids, steroid, diterpines, flavonoids, tannin, glycoside, saponin and phenolic compound. In in-vitro study, Haemonchus worms were exposed to different concentration of hydroethanolic and aqueous extract of Acorus calamus rhizome. The hydroethanolic extract was found to be more effective against Haemonchus contortus than aqueous extract. A dose dependant anthelmintic activity was exhibited by rhizome extract and highest efficacy was observed at 1000 μg/ml. The goats positive for Haemonchosis showed a significant decrease in Hb, PCV, TEC, total serum protein, albumin A:G ration and serum iron and a significant increase in TLC, neutrophil and eosinophil percentage and liver enzymes (ALT and AST). In-vivo anthelmintic study of hydroethanolic extract of Acorus calamus rhizome @ 500 mg/kg b.wt. orally (two doses, 0 day and 21st day) and fenbendazole @ 5 mg/ kg b.wt. orally were given to Haemonchus infected goats. EPG count, haemato-biochemical parameters and clinical improvement were evaluated on ‘0’, 7th, 14th, 21st and 28th day post treatment. In Group I, EPG became 0 on 28th day after administration of second dose on 21st day. In Group II, treated with fenbendazole, EPG count became 0 on 7th day. Haematological parameters showed increase in Hb, PCV, TEC, lymphocyte % and decrease in TLC, neutrophil and eosinophil % post treatment and biochemical analysis showed increase in values of TSP, Serum Albumin, A:G ratio and Serum Iron after treatment. Globulin, ALT and AST values decreased significantly post treatment. On the basis of reduction of EPG count and haemato-biochemical changes, the therapeutic efficacy of hydroethanolic extract of Acorus calamus rhizome was 100% on 28th day post treatment with administration of second dose orally on 21st day. Fenbendazole showed a higher efficacy with 100% reduction of EPG on 7th day post treatment.en_US
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810184846
dc.keywordsANTHELMINTIC ACTIVITY, Acorus calamus RHIZOME EXTRACT, Haemonchus SPECIES, GOATSen_US
dc.language.isoEnglishen_US
dc.pages99p.en_US
dc.publisherCollege of Veterinary Science, Assam Agricultural University, Khanapara, Guwahatien_US
dc.subClinical Veterinary Medicine, Ethics and Jurisprudenceen_US
dc.themeANTHELMINTIC ACTIVITY OF Acorus calamus RHIZOME EXTRACT AGAINST Haemonchus SPECIES IN GOATSen_US
dc.these.typeM.V.Sc.en_US
dc.titleANTHELMINTIC ACTIVITY OF Acorus calamus RHIZOME EXTRACT AGAINST Haemonchus SPECIES IN GOATSen_US
dc.typeThesisen_US
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