STUDY ON ACEPHATE INDUCED IMMUNOTOXICITY AND ITS REVERSAL BY AQUEOUS EXTRACT OF TINOSPORA CORDIFOLIA STEM IN MICE
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Date
2007
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Publisher
Anand Agricultural University, Anand
Abstract
Acephate, a water-soluble insecticide, belongs to the phosphoramidothioate group
of organophosphate (OP) insecticides. It is being widely used for the protection of
vegetables and fruits due to its activity against lepidopterans and aphids. As this
insecticide is in use as crop protectant, it is likely to cause indirect exposure in animals
through contamination of feed, soil and ground water. Herbal plants are believed to
promote positive health and maintain organic resistance against infection by reestablishing
the body's equilibrium and conditioning the body tissues and cause
immunomodulation. Among various plants causing immunomodulation, Tinospora
cordifolia (Guduchi) is important one. Present study was planned to know the toxic effect
of acephate on immune system and reversal effect of Tinospora cordifolia on acephate
induced immunotoxicity in mice
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Keywords
Veterinary Pharmacology, Study