CLINICAL EVALUATION OF DEXMEDETOMIDINE-MIDAZOLAMKETAMINE WITH ATRACURIUM FOR ISOFLURANE ANAESTHESIA IN DOGS
| dc.contributor.advisor | S, Sooryadas | |
| dc.contributor.author | JOSELIN, Binu S | |
| dc.date.accessioned | 2019-02-19T09:30:20Z | |
| dc.date.available | 2019-02-19T09:30:20Z | |
| dc.date.issued | 2018-01-11 | |
| dc.description.abstract | 8. ABSTRACT General anaesthesia with sustained muscle relaxation is inevitable for most of the surgical procedures performed. Additional muscle relaxation, without deepening anaesthesia, could be attained by administering a peripheral acting muscle relaxant like atracurium. Accordingly the study was conducted to find out the clinico-physiological and haemodynamic effects of atracurium on animals induced with dexmedetomidine-midazolam-ketamine combination and maintained on isoflurane for various surgical procedures. The study was conducted in twelve dogs which underwent various surgical procedures, in the Department of Veterinary Surgery and Radiology, College of Veterinary and Animal Sciences, Pookode, Wayanad. These dogs were randomly allocated into two groups – Group I and Group II, of six animals each. Animals of Group I were anaesthetised with a drug combination of dexmedetomidine, midazolam and ketamine at the rate of 5 μg/kg, 0.2 mg/kg and 5 mg/kg body weight respectively as a single intramuscular injection. Following endotracheal intubation, isoflurane was administered in oxygen to maintain anaesthesia. In Group II, following induction with the same injectable drug combination and maintenance with isoflurane, a loading dose of atracurium at the dose rate of 0.1 mg/kg body weight was administered intravenously, immediately followed by a continuous rate infusion of atracurium at a dose rate of 0.1 mg/kg/hour. The quality of anaesthetic induction, produced by the dexmedetomidinemidazolam- ketamine combination was excellent in all the animals. There was profound sedation in all the twelve animals following the intramuscular administration of the injectable anaesthetic combination, and the transition to anaesthesia was calm and smooth. Eyeball rolled ventrally and medially. There was profound relaxation of jaw muscle and laryngeal tone which permitted easy intubation. Respiratory rate reduced in all the animals following induction with the injectable anaesthetic combination. Administration of atracurium in the animals of Group II produced pronounced reduction in the rate and depth of respiration which necessitated manual assisted ventilation for every spontaneous breath. All four muscle twitches were present in the animals of Group I, after induction and during maintenance of anaesthesia. But the twitches, assessed visually, were not as strong as those before administration of the injectable anaesthetic drug combination. The eye ball was positioned ventrally and medially in all the animals of Group I, after induction and during maintenance. There was disappearance of two muscle twitches and central positioning of the eyeballs within five to eight minutes after administration of atracurium. The eyeballs maintained the central position and the third and fourth muscle twitches remained absent up to 20th minute, after which the eyeballs rolled down and the twitches reappeared and remained so throughout the period of anaesthesia. There were no significant variations in the haematological, serum biochemical, blood gas and electrolyte values in both the groups. Time taken for recovery, time to regain sternal recumbency and time to assume standing posture unassisted, following weaning from anaesthesia did not vary significantly in the animals administered with atracurium when compared to the animals of Group I. It could be thus concluded that dogs anaesthetised with intramuscular injection of dexmedetomidine-midazolam-ketamine combination and maintained on isoflurane when administered atracurium intravenously followed immediately by a continuous rate infusion, provided profound muscle relaxation without compromising the haemodynamic functions, but the marked reduction in the rate and depth of respiration necessitated assisted ventilation. | en_US |
| dc.identifier.uri | http://krishikosh.egranth.ac.in/handle/1/5810095845 | |
| dc.language.iso | en | en_US |
| dc.pages | 93 | en_US |
| dc.sub | Veterinary Surgery and Radiology | en_US |
| dc.subject | null | en_US |
| dc.theme | Veterinary surgery and radiology | en_US |
| dc.these.type | M.V.Sc. | en_US |
| dc.title | CLINICAL EVALUATION OF DEXMEDETOMIDINE-MIDAZOLAMKETAMINE WITH ATRACURIUM FOR ISOFLURANE ANAESTHESIA IN DOGS | en_US |
| dc.type | Thesis | en_US |