Synthesis and antimicrobial potential of barbituric acid derivatives

Simple item page
dc.contributor.advisorUtreja, Divya
dc.contributor.authorMadhvi
dc.date.accessioned2023-06-25T06:18:51Z
dc.date.available2023-06-25T06:18:51Z
dc.date.issued2022
dc.description.abstractFunctionalized 5-aryl-pyrimido[4,5-b]quinoline-2,4(1H,3H,5H,10H)-diones were synthesized in high yields using one-pot three-component approach by reacting barbituric acid, aryl aldehydes, aryl amines and p-toluenesulfonic acid as catalyst. These synthesized compounds were characterized with the help of various spectral techniques viz. 1HNMR, 13CNMR, FT-IR spectroscopy and Mass spectrometry. All the synthesized compounds were screened to evaluate their in vitro antimicrobial potential against bacterial strain Dickeya sp. with respect to Gentamicin as standard and against fungal strain Fusarium oxysporum with respect to Carbendazim as standard. It was concluded that the barbituric acid derivatives 8-bromo-5-(4nitrophenyl)pyrimido[4,5-b]quinoline-2,4(1H,3H,5H,10H)-dione (5e) and 8-nitro-5-(4nitrophenyl)pyrimido[4,5-b]quinoline-2,4(1H,3H,5H,10H)-dione (5g) showed better antimicrobial potential at with MIC = 3000 μg/mL and MFC = 5000 μg/mL as compared to the other screened compounds.en_US
dc.identifier.citationMadhvi (2022). Synthesis and antimicrobial potential of barbituric acid derivatives (Unpublished M.Sc. thesis). Punjab Agricultural University, Ludhiana, Punjab, India.en_US
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810197711
dc.keywordsBarbituric acid, p-toluenesulfonic acid, antimicrobial, inhibition zone diameter, Dickeya sp., Fusarium oxysporumen_US
dc.language.isoEnglishen_US
dc.pages68en_US
dc.publisherPunjab Agricultural University, Ludhianaen_US
dc.research.problemSynthesis and antimicrobial potential of barbituric acid derivativesen_US
dc.subChemistryen_US
dc.themeSynthesis and antimicrobial potential of barbituric acid derivativesen_US
dc.these.typeM.Scen_US
dc.titleSynthesis and antimicrobial potential of barbituric acid derivativesen_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Madhavi thesis after viva 31.1.2022.pdf
Size:
2.44 MB
Format:
Adobe Portable Document Format
Description:
M.Sc.
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Thesis