Chemical derivatizations of major constituent of cumin (Cuminum cyminum) and their biological activity

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dc.contributor.advisorSharma, Sunita
dc.contributor.authorPardeep Kaur
dc.date.accessioned2021-09-09T07:04:16Z
dc.date.available2021-09-09T07:04:16Z
dc.date.issued2021
dc.description.abstractCuminum cyminum is an annual herbaceous plant belonging to the family Apiaceae genus Cuminum. In the present study, chemical composition of essential oil and different solvent extracts of cumin of variety GC-4 was determined by GC-MS analysis. Cuminaldehyde was found to be the major constituent present in the essential oil and second major compound present in the different solvent extracts (except chloroform). The proximate analysis of cumin seeds showed that it contains 8.58±0.20, total minerals 8.62±0.05, crude protein 14.43±0.02, crude fibre 11.06±0.01, fats 15.00±0.04, total sugars 2.30±0.21 and total carbohydrates 40.01±0.06. Elemental investigation of cumin seeds showed that it contains micronutrients like Iron: 181.33, copper: 14.25, manganese: 25.75, zinc: 31.25, chromium: 10.15, nickel: 2.38, cobalt: 2.05, cadmium: 2.03, lead: 58.75, arsenic: 118.50 in parts per million concentrations. Phytochemical study revealed that various phytochemicals viz alkaloids, saponins, tannins, coumarins, amino acids, flavonoids, proteins, phenols and carbohydrates were present in different solvent extracts. Aqueous extract of cumin seeds was used as a bioreductant for the synthesis of silver nanoparticles. Different derivatives i.e. Schiff Bases, hydrazones, thiosemicarbazones, chalcones and pyrazolines of major constituent of essential oil namely cuminaldehyde (isolated from essential oil by column chromatography) were synthesized. Characterization of synthesized compounds was done using UV-visible, FT-IR, 1 H and 13C NMR. Essential oil, different solvent extracts, silver nanoparticles, cuminaldehyde and its derivatives were screened for their antioxidant (via DPPH assay), microbial (against Pseudomonas sp., Klebsiella sp. and Enterobacter sp.) and fungicidal potential (against Fusarium wilt, Ascochyta blight and Bortrytis gray mould. Cuminaldehyde derivatives were found more effective as compared to cumin essential oil, its major constituent, different solvent extracts of cumin seeds and silver nanoparticles synthesized from aqueous cumin seed extract.en_US
dc.identifier.citationPardeep Kaur (2021). Chemical derivatizations of major constituent of cumin (Cuminum cyminum) and their biological activity (Unpublished Ph.D. Dissertation). Punjab Agricultural University, Ludhiana, Punjab, India.en_US
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810175559
dc.keywordsCuminum cymminum, Phytochemicals, Proximate composition, GC-MS, Cuminaldehyde, Antioxidant, Antimicrobial, Fungicidal activityen_US
dc.language.isoEnglishen_US
dc.pages181en_US
dc.publisherPunjab Agricultural University, Ludhianaen_US
dc.research.problemChemical derivatizations of major constituent of cumin (Cuminum cyminum) and their biological activityen_US
dc.subChemistryen_US
dc.themeChemical derivatizations of major constituent of cumin (Cuminum cyminum) and their biological activityen_US
dc.these.typePh.Den_US
dc.titleChemical derivatizations of major constituent of cumin (Cuminum cyminum) and their biological activityen_US
dc.typeThesisen_US
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