“TOXICOPATHOLOGY OF ROSUVASTATIN AND THIAZOLIDINEDIONES (ROSIGLITAZONE AND PIOGLITAZONE) IN MALE RATS
Loading...
Date
2009
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Anand Agricultural University, Anand
Abstract
Rosuvastatin is among of the most effective treatment of hyperlipidemia and
dyslipidemia by providing an important and effective approach for lipid lowering agents.
Thiazolidinediones (rosiglitazone and pioglitazone) are most commonly prescribed in
patients with type 2 diabetes mellitus to lower blood glucose levels. The present research
work was conducted to evaluate the repeated dose toxicity of rosuvastatin and
thiazolidinediones (rosiglitazone and pioglitazone) in Sprague Dawley male rats. The
animals were divided in 7 different groups with 6 male animals in each group. The
groups I, II, III, and IV were administered vehicle control (0 mg/kg), rosuvastatin (50
mg/kg), rosiglitazone (80 mg/kg), and pioglitazone (300 mg/kg) in individual treatment
groups respectively. The groups V, VI and VII were treated in different combinations with
rosuvastatin (50mg/kg) + rosiglitazone (80mg/kg); rosiglitazone (40mg/kg) +
pioglitazone (150mg/kg) and rosiglitazone (80mg/kg) + pioglitazone (300mg/kg)
respectively by oral dosage for 28 days.
Description
Keywords
Veterinary Pathology, Study