Developmental Toxicity Study of Glyphosate-Based Herbicide in Wistar Rats

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dc.contributor.advisorKarande, V. V.
dc.contributor.authorLote Dhanashree Dadabhau
dc.date.accessioned2024-11-05T05:43:49Z
dc.date.available2024-11-05T05:43:49Z
dc.date.issued2024-04-10
dc.description.abstractThe present study was planned to determine the developmental toxicity of glyphosate-based herbicide in Wistar rats. A total of 110 animals were used in the study and divided into three phases: acute toxicity, sub-acute toxicity, pre and post-natal toxicity. An acute toxicity study was performed as per OECD guideline 423 which revealed the LD50 of GBH between 2500 to 5000mg/kg body weight with signs of salivation, gasping, frothy discharge, bleeding from the nose, squinted eyes, diarrhoea, and death. However, all toxicological signs resolved after 72 hours of dosing. Sub-acute toxicity study involved 40 female rats grouped as T1, T2, T3, and T4 and administered GBH at 0, 500, 1000, 1500mg/kg. The study was conducted as per OECD guideline 407. GBH was administered orally by gavage needle for 28 days. The body weight (g) was recorded on 0, 7th, 14th, 21st, and 28th day. Body weight was significantly increased initially but at the end of the experiment significantly reduced in groups receiving higher doses. Hematological parameters were significantly decreased in the treatment groups compared to the control group. The biochemical parameters such as Cr, SGOT, SGPT, and ALP were significantly increased in the treatment groups compared to the control group. Histopathological examination revealed degenerative changes and mild to moderate necrosis, and congestion in the liver, kidney, heart, and stomach compared to the control group. The developmental toxicity study involved 40 females and 20 males grouped as T1, T2, T3,and T4 and dosed at 750, 500, and 300mg/kg, respectively and T4 was kept as control and administered for 14 days before mating till PND 13th. In-utero fetal development was assessed on 17th day of pregnancy. The blood parameters were assessed on 21st day of pregnancy. The data revealed that the exposure of GBH at different doses, different time intervals and in different physiological conditions of animals may cause adverse effects on body weight, hematological, and biochemical parameters of the developing animal. Long term exposure of glyphosate-based herbicide may cause toxic effects and also produce developmental defects in next generations. Hence, judicial use of such hazardous chemicals are necessary.
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810216019
dc.keywordsVeterinary Pharmacology
dc.keywordsVeterinary Toxicology
dc.keywordsToxicity Study
dc.keywordsGlyphosate
dc.keywordsHerbicide
dc.keywordsWistar Rat
dc.language.isoEnglish
dc.pages156
dc.publisherMAFSU, Nagpur
dc.subVeterinary Pharmacology and Toxicology
dc.themeToxicity Study of Glyphosate-Based Herbicide in Wistar Rats
dc.these.typeM.V.Sc.
dc.titleDevelopmental Toxicity Study of Glyphosate-Based Herbicide in Wistar Rats
dc.typeThesis
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