SUB-ACUTE TOXICITY OF MANCOZEB ALONE AND IN-COMBINATION WITH ARSENIC IN WISTAR RAT

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dc.contributor.advisorVerma, Pawan Kumar
dc.contributor.authorYousuf, Rasia
dc.date.accessioned2022-10-25T06:20:03Z
dc.date.available2022-10-25T06:20:03Z
dc.date.issued2022-09-19
dc.description.abstractThe aim of present study was to determine the impact of toxic interaction between Mancozeb (MZ) and arsenic (As) on erythrocytes, brain, liver, kidney and testicular tissue of rats and to compare ameliorative potential of quercetin and catechin against the induced toxicity. Sixty adult male rats were randomly allocated into 10 groups with 6 animals in each. Group I served as control, group II was exposed with MZ (800 mg/kg, b. wt, PO). Group III, IV and V were exposed with drinking water containing sodium arsenite at the rate of 10, 50 and 100 ppb continue for 28 days, respectively. Group VI, VII and VIII were treated with sodium arsenite containing drinking water at 10, 50 and 100 ppb respectively along with MZ for 28 days. Group IX and X were given sodium arsenite in drinking water at 100 ppb and MZ at 800 mg/kg, b. wt. PO along with quercetin and catechin at the same dose (50 mg/kg), respectively. A significant (p0.05) alteration was seen in hepatic, renal biomarkers along with alterations in the tissue antioxidant status in different tissues of MZ treated rats in comparison to control. Exposure to different doses of arsenic (10, 50, 100ppb) also produced a dose dependent effect on these biomarkers. Co-exposure of toxicants potentiated the toxic effects exhibited by biochemical, oxidative and histopathological alterations in different tissues. In contrast, administration of toxicants along with quercetin or catechin markedly attenuated the alterations in biochemical, oxidative biomarkers and histopathological alterations.en_US
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810189350
dc.keywordsARSENIC, MANCOZEB, QUERCETIN, ANTIOXIDANT, CATECHIN.en_US
dc.language.isoEnglishen_US
dc.pages134pen_US
dc.publisherSher-e-Kashmir University of Agricultural Sciences & Technology of Jammu (J&K)en_US
dc.research.problemSUB-ACUTE TOXICITY OF MANCOZEB ALONE AND IN-COMBINATION WITH ARSENIC IN WISTAR RATen_US
dc.subVeterinary Pharmacology and Toxicologyen_US
dc.themeSUB-ACUTE TOXICITY OF MANCOZEB ALONE AND IN-COMBINATION WITH ARSENIC IN WISTAR RATen_US
dc.these.typeM.V.Sc.en_US
dc.titleSUB-ACUTE TOXICITY OF MANCOZEB ALONE AND IN-COMBINATION WITH ARSENIC IN WISTAR RATen_US
dc.typeThesisen_US
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