Identification of Polymorphism in Bovine CYP1A1 gene segment by SSCP and DNA Sequencing
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Date
2008
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Publisher
Anand Agricultural University, Anand
Abstract
The most important drug metabolizing enzyme family, Cytochrome P450
(CYP) is one of the conserved entities among species. The cytochrome P450 enzyme
system is responsible for the metabolism and clearance of a wide array of drugs,
toxins and endogenous substrates. The family is involved in metabolism of 70 – 80%
of drugs, nutrients, endogenous substances and environmental toxins. Studies
concerning Cytochrome P450 polymorphism, expression and regulation have received
very little attention in veterinary species (e.g. cattle, swine, poultry), compared to man
and laboratory animals. These species are often exposed to drugs, pesticides or
pollutants potentially harmful
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Keywords
Animal Biotechnology, Analysis