STUDIES ON EFFECT OF FLUNIXIN MEGLUMINE AND FEBRILE CONDITION ON PHARMACOKINETICS OF CEFPIROME AND SAFETY OF SIMULTANEOUS ADMINISTRATION OF CEFPIROME AND FLUNIXIN MEGLUMINE IN SHEEP
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Date
2020
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Abstract
Cefpirome is a novel fourth generation cephalosporin with bactericidal action. Synergistic interaction between NSAID and antibiotic can potentially prevent the emergence of resistance, increase antibacterial efficacy and provide broader-spectrum of antibacterial activity than antibiotic monotherapy. Flunixin meglumine (FM) is used as adjunctive therapy in the treatment of sepsis and various inflammatory conditions in different ruminant species. Along with this fact, fever is also one of the most common manifestations in bacterial diseases. Looking to these overall points, the study was conducted to evaluate the effect of intramuscularly administered FM (1.1 mg/kg) and lipopolysaccharide (LPS) induced febrile condition on pharmacokinetics of cefpirome following intravenous (IV) and intramuscular (IM) administrations (10 mg/kg) in sheep and safety of simultaneous administrations of cefpirome (10 mg/kg, IM) with FM (1.1 mg/kg, IM) for five days in sheep by monitoring hematological and blood biochemical profiles, as these kinds of literature is not available in sheep. Cefpirome was assayed in plasma by HPLC.