Synthesis of novel 1,2,4-triazolosulfonamides as antifungal agents against phytopathogenic fungi

Simple item page
dc.contributor.advisorAnajli
dc.contributor.authorLovepreet Kaur
dc.date.accessioned2018-11-10T06:22:49Z
dc.date.available2018-11-10T06:22:49Z
dc.date.issued2018
dc.description.abstractA series of 1,2,4-triazolosulfonamides was synthesized by microwave irradiation method in excellent yield, using sulfonyl chlorides and 1,2,4-triazoles as starting materials. The products were characterized by FT-IR, 1H NMR, 13C NMR and screened for their antifungal potential against various phytopathogenic fungi viz. Alternaria alternata, Curvularia lunata, and Helminthosporium oryzae by poisoned food technique in terms of ED50 values. The synthesized compounds displayed moderate to significant activity. Among all test compounds, 4-Methyl-N-(1H-1,2,4-triazol-3-yl)benzenesulfonamide (4) and 4-Methyl-N-(4H- 1,2,4-triazol-4-yl)benzenesulfonamide (7) showed best antifungal activity against all test fungi with respective ED50 values 4.0 and 3.4 μg ml-1 against Alternaria alternata, 2.3 and 2.0 μg/ml against Curvularia lunata and 3.5 and 3.0 μg/ml against Helminthosporium oryzae, multifold lower than the standard fungicides used, Tilt and Captan. The results were rationalized on the basis of in silico analysis viz. Toxicity analysis, Docking analysis and Lipinski parameters.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810083119
dc.keywordstriazolosulfonamides, Microwave Irradiation, Antifungal activity, Toxicity, Docking, Lipinski parametersen_US
dc.language.isoenen_US
dc.pages60en_US
dc.publisherPunjab Agricultural University, Ludhianaen_US
dc.research.problemSynthesis of novel 1,2,4-triazolosulfonamides as antifungal agents against phytopathogenic fungien_US
dc.subChemistryen_US
dc.subjectnullen_US
dc.themeSynthesis of novel 1,2,4-triazolosulfonamides as antifungal agents against phytopathogenic fungien_US
dc.these.typeM.Scen_US
dc.titleSynthesis of novel 1,2,4-triazolosulfonamides as antifungal agents against phytopathogenic fungien_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
LOVEPREET.PDF.pdf
Size:
22.65 MB
Format:
Adobe Portable Document Format
Description:
M.Sc.
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Thesis