Ochratoxicosis in quails (Coturnix coturnix japonica) with special reference to Inununopathological response

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dc.contributor.advisorRajan, A
dc.contributor.authorAmir Abbas, Farshid
dc.contributor.authorKAU
dc.date.accessioned2020-02-24T10:41:49Z
dc.date.available2020-02-24T10:41:49Z
dc.date.issued1992
dc.descriptionPhDen_US
dc.description.abstractIn this investigation the pathological effects of OA in quail embryo and adult quail were studied with special reference to the immune system. Ochratoxin A (OA) was inoculated into the quail embryos, at the dose rate of 0.02 ^g per embryo. There was 68.66 per cent mortality which clearly indicated the direct action of OA. The embryos which were sacrificed on the 13th and 16th day of incubation showed significant reduction in the body weight, weight of bursa of Fabricius, spleen and thymus. Histological changes in these lymphoid organs were, atrophy, necrosis and depletion of lymphoid elements. Ultrastructurally the changes were time dependent. There were changes in the shape of the nucleus with condensation of granular and fibrillar components of the nucleoli. The adverse immunobiological effect of OA on the developing lymphoid organs was established by histological and ultra structural studies. OA at the dose rate of 50 /ag/bird/day for a period of 60 days was administered through oesophageal intubation. Pathological changes were sequentially documented with special reference to the immune system. In the OA fed quails, the clinical signs included emaciation and hyperexcitation at the later part of the experiment. There was highly significant reduction in the body weight, weight of bursa of Fabricius, spleen and thymus. The reduction in the weight of lymphoid organs gave evidence to the adverse effects of OA on the immune system. There was reduction in the total erythrocyte count (TEC), haemoglobin (Hb) concentration and packed cell volume in OA fed birds indicating the significant damaging effect on the haemopoietic sytem. Estimation of total serum protein (TSP), serum globulin (SGI) and serum immunoglobulin fractions clarified the biological adverse effect of OA on the humoral immune system. Highly significant reduction in total leukocyte count (TLC) and T cell dependent lymphopenia proved the immunosuppressive effect of OA. There was reduction in T cells, increase migration indices in response to Fowl pox antigen in leukocyte migration inhibition test (LMIT), the reduction in the cutaneous response to 2,4-dinitrochlorobenzene (DNCB) and phytohaemagglutinin-M (PHA-M) and spleen indices in the graft versus host reaction (GVHR), clarified the immunotoxicity of OA on the cell-mediated immune system.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810143496
dc.keywordsOchratoxins, OA on embryo, Japanese quail, Laboratory animals, Avian species, Pathological features of ochratoxicosisen_US
dc.language.isoenen_US
dc.publisherCentre of Excellence in Pathology, College of Veterinary and Animal Sciences, Mannuthyen_US
dc.subVeterinary Pathologyen_US
dc.subjectnullen_US
dc.themeOchratoxicosis in Quailsen_US
dc.these.typePh.Den_US
dc.titleOchratoxicosis in quails (Coturnix coturnix japonica) with special reference to Inununopathological responseen_US
dc.typeThesisen_US
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