RECEPTOR PHARMACOLOGY OF PHYTOL ON RAT INTESTINE

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dc.contributor.advisorSanis Juliet
dc.contributor.authorMEGHA MADHUSUDHANAN
dc.date.accessioned2023-03-17T09:43:25Z
dc.date.available2023-03-17T09:43:25Z
dc.date.issued2022-02-15
dc.descriptionSubmitted in partial fulfilment of the requirement for the degree of MASTER OF VETERINARY SCIENCE in Veterinary Pharmacology and Toxicologyen_US
dc.description.abstractReceptors act as mediators between the drug molecule and the physiological responses elicited. The activity of any compound depends on its interaction with the intracellular and trans-membrane receptors. Receptor binding and functional assays help in characterisation of novel receptors and receptor subtypes. Phytol is a diterpenoid has gained importance in therapeutics recently because of its numerous pharmacological activities. The studies on interaction of phytol with known classical receptors are meagre in the literature. Therefore, the present study was undertaken to assess the binding of phytol with the muscarinic, GABAnergic and histaminergic receptors in rat ileum using a Digital Dales mono bath with isometric transducer. The EC50 and IC50 of phytol in presence of agonist and antagonist of muscarinic cholinergic, GABAergic and histaminergic receptors were derived. Pre-treatment with submaximal doses of phytol attenuated the contractile response to acetylcholine (ACh). The activity of phytol as a muscarinic blocker was comparable with that of solifenacin while the relaxation potential for subsidence of pre-contracted intestine with ACh was incomplete and less effective. The response of phytol in presence of GABA and histamine receptor agonists and antagonists were not well appreciated. In conclusion, phytol produced weak spasmolytic effect in the rat ileum mediated through muscarinic receptors. Further, downstream pathway studies are required to understand the mechanism by which phytol induced relaxation of the rat ileum.en_US
dc.identifier.urihttps://krishikosh.egranth.ac.in/handle/1/5810195363
dc.keywordsPHARMACOLOGY OF PHYTOL ON RAT INTESTINE, RECEPTOR PHARMACOLOGY OF PHYTOL, RAT, ROLE OF CLASSICAL RECEPTORS ON REGULATION OF INTESTINAL SMOOTH MUSCLE ACTIVITY, MUSCARINIC RECEPTOR, GABA RECEPTORS, HISTAMINE RECEPTORS , SECONDARY METABOLITES FROM PLANTS AS RECEPTOR LIGANDS INVOLVED IN REGULATION OF INTESTINAL SMOOTH MUSCLE ACTIVITY, DITERPENOIDS AS RECEPTOR LIGANDS, PHYTOL, PREPARATION OF DRUG STANDARDS AND PHYSIOLOGICAL SOLUTIONS, ISOMETRIC TENSION RECORDING , MUSCLE TENSION EXPERIMENT ,en_US
dc.language.isoEnglishen_US
dc.pages92 p.en_US
dc.publisherCOLLEGE OF VETERINARY AND ANIMAL SCIENCES POOKODEen_US
dc.research.problemQuantitative assessment of phytol induced muscarinic cholinergic, gamma- aminobutyric acid (GABA) and histamine receptor responses in the rat ileumen_US
dc.subVeterinary Pharmacology and Toxicologyen_US
dc.themePHARMACOLOGY OF PHYTOL ON RAT INTESTINEen_US
dc.these.typeM.V.Sc.en_US
dc.titleRECEPTOR PHARMACOLOGY OF PHYTOL ON RAT INTESTINEen_US
dc.typeThesisen_US
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