STUDIES ON TOXICOIMMUNOPATHOLOGY OF CYCLOSPORIN A IN WISTAR RATS”
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Date
2008
Authors
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Publisher
Anand Agricultural University
Abstract
The present study was conducted on 6-8 weeks old Wistar rats. Forty eight
Wistar rats divided in to four different groups with equal numbers of male and female.
Group I was served as vehicle control. Group II, III and IV were administered with 5,
20 and 40 mg of CsA per kg body weight daily once by oral intubation for 28 days.
All the animals were monitored for any observable toxic symptoms and mortality
throughout the experimental period. All the animals were weighed weekly to monitor
body weight gain. The food consumption was also measured once a week. After
completion of 28 days of administration of CsA the blood samples were collected
from sublingual vein for haematological, biochemical and immunological
investigations where as urine was collected for urine analysis. After terminal sacrifice
all the animals were subjected to necropsy and organs
Description
Keywords
Veterinary Pathology, Study