ECO-FRIENDLY SYNTHESIS OF AMIDES AND THEIR MICROBIAL ACTIVITY IN SOYBEAN

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dc.contributor.authorTANIA BANSAL
dc.date.accessioned2017-07-24T12:21:23Z
dc.date.available2017-07-24T12:21:23Z
dc.date.issued2013
dc.description.abstractKnoevengal condensation reaction was used for the synthesis of α, β- unsaturated acids. The different aldehydes viz., benzaldehyde, 2-chlorobenzaldehyde, 4-chlorobenzaldehyde, 2-nitrobenzaldehyde and 3-nitrobenzaldehyde were reacted with phenoxyacetic acid in the presence of sodium ethoxide to give the corresponding acrylic acids. These acrylic acids were reacted with 4-aminophenazone and morpholine in the presence of catalytic amount of boric acid to synthesize corresponding acrylamides. Similarly the synthesized acrylic acids were reacted with 4-amino 1, 2, 4 triazole to form corresponding acrylamides using boric acid as catalyst. Physical data (yield, melting point, state and colour) of synthesized acids and amides were determined. All the synthesized acids and amide derivatives were characterized by spectral data (FTIR, 1H NMR and 13C NMR ). All amide derivatives were also prepared by microwave irradiation method by irradiating the mixture of corresponding acrylic acids and amines. Amide derivatives were screened for their microbial activity against Ensifer sp. (LSR 3), Pseudomonas sp. (PGPR 3), S. aureus and E.coli. It was found that the synthesized amide derivatives showed mild to moderate inhibition against Ensifer sp., Pseudomonas sp. and S.aureus whereas these were found good inhibitory against E.coli. So overall it was observed that microwave irradiation method gave better yield and took less time as compared to conventional method. The compounds having triazole series of amides were more effective against bacteria than the compounds containing morpholine and phenazone moiety.en_US
dc.identifier.urihttp://krishikosh.egranth.ac.in/handle/1/5810026072
dc.language.isoenen_US
dc.subChemistryen_US
dc.subjectnullen_US
dc.themeSOYBEANen_US
dc.these.typeM.Scen_US
dc.titleECO-FRIENDLY SYNTHESIS OF AMIDES AND THEIR MICROBIAL ACTIVITY IN SOYBEANen_US
dc.typeThesisen_US
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