TOXICOPATHOLOGICAL STUDIES OF ACETYL SALICYLIC ACID, NIMESULIDE AND DICLOFENAC SODIUM IN BROILER CHICKS.
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Date
2014
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Publisher
AAU, Anand
Abstract
The present research work was conducted on eight groups of day old Cobb-400 broiler chicks to study the toxicopathological effects of acetyl salicylic acid, nimesulide and diclofenac sodium in feed. Group I was kept as control. Group II was administered with diclofenac at dose of 15 ppm through feed. Groups III, IV and V were fed with diet containing acetyl salicylic acid @ 400, 1600 and 4000 ppm respectively for 21 days. Groups VI, VII and VIII were fed with diet containing nimesulide@ 40, 80 and 160 ppm respectively for 21 days. The chicks were observed for any abnormal behavioral signs and mortality during the experiment. After completion of 21 days treatment, blood samples were collected for hematology and serum biochemical analysis from right jugular vein. The survived birds were sacrificed by means of cervical dislocation at the end of experiment. A detailed post mortem examination was performed on chicks which died during the experiment as well as sacrificed at the end of the experiment and gross lesions were recorded. Tissue samples (liver, kidney, heart, intestine, spleen and lung) were collected in 10% formalin for histopathological examination.
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Keywords
Veterinary science, VETERINARY PATHOLOGY, study